ID   INT9_DICDI              Reviewed;         712 AA.
AC   Q54SH0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Integrator complex subunit 9 homolog;
GN   Name=ints9; ORFNames=DDB_G0282473;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66096.1; -; Genomic_DNA.
DR   RefSeq; XP_640069.1; XM_634977.1.
DR   AlphaFoldDB; Q54SH0; -.
DR   SMR; Q54SH0; -.
DR   STRING; 44689.DDB0234099; -.
DR   PaxDb; Q54SH0; -.
DR   PRIDE; Q54SH0; -.
DR   EnsemblProtists; EAL66096; EAL66096; DDB_G0282473.
DR   GeneID; 8623598; -.
DR   KEGG; ddi:DDB_G0282473; -.
DR   dictyBase; DDB_G0282473; ints9.
DR   eggNOG; KOG1138; Eukaryota.
DR   HOGENOM; CLU_023159_1_0_1; -.
DR   InParanoid; Q54SH0; -.
DR   OMA; CADSIKD; -.
DR   PhylomeDB; Q54SH0; -.
DR   PRO; PR:Q54SH0; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..712
FT                   /note="Integrator complex subunit 9 homolog"
FT                   /id="PRO_0000342371"
FT   REGION          47..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   712 AA;  81490 MW;  E4C702E4AE344916 CRC64;
     MKVHCLSQSA QSPCFLLEYK NVKILLDCAL EISSILHFLP KNLNYNNNNN NNNNNNNNNN
     NNNNNNNNNN SYSFKEKDKE LNQFFKNING TLYIDNGCSN IKYNCPQFEM IDDFSTIDMI
     LISNYTNIYA LPFITEYTNF QGKIYATEPT VQIGKLLLEE LVQMDKQYSN SSINNNNNNN
     NLSDCWQNIE ILEKLNVHNV GMENENLYRD SYRWKDLYKK IDIEKSFEKI QSIRFNESIK
     HYGFECIPSS SGYGLGSANW VIESKGFERV VYISDSSLSL SRYPTPFQLS PIDNPDVLIL
     SKINHYPNNP PDQMLSELCS NIGSTLQQGG TVLIPSYSCG IILDLFEHLA DYLNKVGLPY
     VPIYFVSSVS KAVLSYADIY SEWLNKSKQE RAFMPETPFL HQDLMRKGQF QAYQHVHSNF
     QANDPCIIFT GHPSCRIGDI TTLIKLYDNP KNSILLIEPD FDFKSTVLPF SKQISRIQFL
     PIDPRINFNE ANLLISKLSP KHLIIPRIYK NYVKNKHSNG NFGIVTTILP LDTIKIQNNQ
     NFESGFIDKE LAQTIQTKVL DKSSQLKNNT TTTTTTTINN QQPIHVAEIS GVLSMSDHEL
     IISPPNISDS NKIIHIKEKF IWGTLSIENI IKAINSTKQF KNNGDSIEYF EINENYYLIK
     ISSKNKTNNN NNSDQVTNIH LSPQNVNIET SCETTRRLIS DIVLLNCNGF YV