INT9_HUMAN
ID INT9_HUMAN Reviewed; 658 AA.
AC Q9NV88; B7Z560; B7Z6M5; O00224; Q8TB16;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Integrator complex subunit 9;
DE Short=Int9;
DE AltName: Full=Protein related to CPSF subunits of 74 kDa;
DE Short=RC-74;
GN Name=INTS9; Synonyms=RC74;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 163-658.
RA Adams M.D.;
RT "Human chromosome 8 BAC clone CIT987SK-2A8 complete sequence.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE INTEGRATOR
RP COMPLEX.
RX PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA Shiekhattar R.;
RT "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT associates with the C-terminal repeat of RNA polymerase II.";
RL Cell 123:265-276(2005).
RN [6]
RP IDENTIFICATION, SUBCELLULAR LOCATION, AND INTERACTION WITH CPSF3L.
RX PubMed=15684398; DOI=10.1128/mcb.25.4.1489-1500.2005;
RA Dominski Z., Yang X.-C., Purdy M., Wagner E.J., Marzluff W.F.;
RT "A CPSF-73 homologue is required for cell cycle progression but not cell
RT growth and interacts with a protein having features of CPSF-100.";
RL Mol. Cell. Biol. 25:1489-1500(2005).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=23904267; DOI=10.1091/mbc.e13-05-0254;
RA Jodoin J.N., Sitaram P., Albrecht T.R., May S.B., Shboul M., Lee E.,
RA Reversade B., Wagner E.J., Lee L.A.;
RT "Nuclear-localized Asunder regulates cytoplasmic dynein localization via
RT its role in the integrator complex.";
RL Mol. Biol. Cell 24:2954-2965(2013).
RN [8]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-58, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Component of the Integrator (INT) complex, a complex involved
CC in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC 3'-box-dependent processing. The Integrator complex is associated with
CC the C-terminal domain (CTD) of RNA polymerase II largest subunit
CC (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable).
CC Mediates recruitment of cytoplasmic dynein to the nuclear envelope,
CC probably as component of the INT complex (PubMed:23904267).
CC {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144).
CC Interacts with ESRRB, ESRRB is probably not a core component of the
CC multiprotein complex Integrator and this association is a bridge for
CC the interaction with the multiprotein complex Integrator; attracts the
CC transcriptional machinery (By similarity).
CC {ECO:0000250|UniProtKB:Q8K114, ECO:0000269|PubMed:16239144}.
CC -!- INTERACTION:
CC Q9NV88; Q5TA45: INTS11; NbExp=16; IntAct=EBI-2866634, EBI-748258;
CC Q9NV88; Q96HW7: INTS4; NbExp=2; IntAct=EBI-2866634, EBI-5663129;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15684398,
CC ECO:0000269|PubMed:23904267}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NV88-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NV88-2; Sequence=VSP_043011;
CC Name=3;
CC IsoId=Q9NV88-3; Sequence=VSP_044306;
CC -!- MISCELLANEOUS: Although strongly related to RNA-specific endonuclease
CC proteins, it lacks the HXHXDH motif that binds zinc and participates in
CC the catalytic center. Its function as endonuclease is therefore unsure.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB67601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK001733; BAA91867.1; -; mRNA.
DR EMBL; AK298468; BAH12796.1; -; mRNA.
DR EMBL; AK300593; BAH13311.1; -; mRNA.
DR EMBL; AC040975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025267; AAH25267.1; -; mRNA.
DR EMBL; U96629; AAB67601.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK005726; DAA05726.1; -; mRNA.
DR EMBL; BK005674; DAA05670.1; -; mRNA.
DR CCDS; CCDS34873.1; -. [Q9NV88-1]
DR CCDS; CCDS55215.1; -. [Q9NV88-3]
DR CCDS; CCDS55216.1; -. [Q9NV88-2]
DR RefSeq; NP_001138631.1; NM_001145159.2. [Q9NV88-2]
DR RefSeq; NP_001166033.1; NM_001172562.1. [Q9NV88-3]
DR RefSeq; NP_060720.2; NM_018250.3. [Q9NV88-1]
DR PDB; 5V8W; X-ray; 2.10 A; A/C/E/G=581-658.
DR PDB; 7BFP; EM; 3.50 A; A=1-658.
DR PDB; 7BFQ; EM; 3.50 A; A=1-658.
DR PDB; 7CUN; EM; 3.50 A; I=1-658.
DR PDB; 7PKS; EM; 3.60 A; i=1-658.
DR PDBsum; 5V8W; -.
DR PDBsum; 7BFP; -.
DR PDBsum; 7BFQ; -.
DR PDBsum; 7CUN; -.
DR PDBsum; 7PKS; -.
DR AlphaFoldDB; Q9NV88; -.
DR SMR; Q9NV88; -.
DR BioGRID; 120874; 64.
DR ComplexPortal; CPX-6441; Integrator complex.
DR CORUM; Q9NV88; -.
DR IntAct; Q9NV88; 15.
DR MINT; Q9NV88; -.
DR STRING; 9606.ENSP00000429065; -.
DR iPTMnet; Q9NV88; -.
DR PhosphoSitePlus; Q9NV88; -.
DR BioMuta; INTS9; -.
DR DMDM; 119371246; -.
DR EPD; Q9NV88; -.
DR jPOST; Q9NV88; -.
DR MassIVE; Q9NV88; -.
DR MaxQB; Q9NV88; -.
DR PaxDb; Q9NV88; -.
DR PeptideAtlas; Q9NV88; -.
DR PRIDE; Q9NV88; -.
DR ProteomicsDB; 6659; -.
DR ProteomicsDB; 82760; -. [Q9NV88-1]
DR ProteomicsDB; 82761; -. [Q9NV88-2]
DR Antibodypedia; 23131; 140 antibodies from 24 providers.
DR DNASU; 55756; -.
DR Ensembl; ENST00000416984.6; ENSP00000398208.2; ENSG00000104299.15. [Q9NV88-2]
DR Ensembl; ENST00000521022.6; ENSP00000429065.1; ENSG00000104299.15. [Q9NV88-1]
DR Ensembl; ENST00000521777.5; ENSP00000430943.1; ENSG00000104299.15. [Q9NV88-3]
DR GeneID; 55756; -.
DR KEGG; hsa:55756; -.
DR MANE-Select; ENST00000521022.6; ENSP00000429065.1; NM_018250.4; NP_060720.2.
DR UCSC; uc003xha.4; human. [Q9NV88-1]
DR CTD; 55756; -.
DR DisGeNET; 55756; -.
DR GeneCards; INTS9; -.
DR HGNC; HGNC:25592; INTS9.
DR HPA; ENSG00000104299; Low tissue specificity.
DR MIM; 611352; gene.
DR neXtProt; NX_Q9NV88; -.
DR OpenTargets; ENSG00000104299; -.
DR PharmGKB; PA162392192; -.
DR VEuPathDB; HostDB:ENSG00000104299; -.
DR eggNOG; KOG1138; Eukaryota.
DR GeneTree; ENSGT00390000001445; -.
DR InParanoid; Q9NV88; -.
DR OMA; CADSIKD; -.
DR OrthoDB; 617493at2759; -.
DR PhylomeDB; Q9NV88; -.
DR TreeFam; TF314100; -.
DR PathwayCommons; Q9NV88; -.
DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR SignaLink; Q9NV88; -.
DR SIGNOR; Q9NV88; -.
DR BioGRID-ORCS; 55756; 796 hits in 1086 CRISPR screens.
DR ChiTaRS; INTS9; human.
DR GeneWiki; INTS9; -.
DR GenomeRNAi; 55756; -.
DR Pharos; Q9NV88; Tbio.
DR PRO; PR:Q9NV88; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9NV88; protein.
DR Bgee; ENSG00000104299; Expressed in secondary oocyte and 145 other tissues.
DR ExpressionAtlas; Q9NV88; baseline and differential.
DR Genevisible; Q9NV88; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0032039; C:integrator complex; IDA:HGNC-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IC:ComplexPortal.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0016180; P:snRNA processing; IDA:HGNC-UCL.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027074; Integrator_9su.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR46094; PTHR46094; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SUPFAM; SSF56281; SSF56281; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Isopeptide bond; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..658
FT /note="Integrator complex subunit 9"
FT /id="PRO_0000259557"
FT REGION 548..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 58
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044306"
FT VAR_SEQ 67..87
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043011"
FT CONFLICT 324
FT /note="V -> A (in Ref. 1; BAA91867)"
FT /evidence="ECO:0000305"
FT STRAND 2..5
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 15..19
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 22..25
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 33..37
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 47..51
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 65..67
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 68..71
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 74..79
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 89..91
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 93..96
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 97..100
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 110..116
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 121..125
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 127..145
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 155..158
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 159..164
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 167..170
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 184..193
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 194..196
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 203..205
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 209..215
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 223..228
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 233..237
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 245..247
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 252..255
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 259..263
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 274..291
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 295..298
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 301..303
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 304..319
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 326..329
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 333..342
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 349..352
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 360..362
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 363..367
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 369..372
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 373..378
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 379..381
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 382..386
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 392..396
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 398..404
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 405..413
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 415..417
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 419..422
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 425..427
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 429..433
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 434..436
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 441..445
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 454..464
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 467..472
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 473..476
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 501..504
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 511..516
FT /evidence="ECO:0007829|PDB:7BFP"
FT TURN 518..520
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 521..524
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 529..534
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 536..539
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 542..547
FT /evidence="ECO:0007829|PDB:7BFP"
FT STRAND 550..554
FT /evidence="ECO:0007829|PDB:7BFP"
FT HELIX 591..600
FT /evidence="ECO:0007829|PDB:5V8W"
FT STRAND 607..610
FT /evidence="ECO:0007829|PDB:5V8W"
FT STRAND 612..619
FT /evidence="ECO:0007829|PDB:5V8W"
FT HELIX 621..623
FT /evidence="ECO:0007829|PDB:5V8W"
FT STRAND 624..629
FT /evidence="ECO:0007829|PDB:5V8W"
FT STRAND 632..639
FT /evidence="ECO:0007829|PDB:5V8W"
FT HELIX 641..652
FT /evidence="ECO:0007829|PDB:5V8W"
FT STRAND 655..657
FT /evidence="ECO:0007829|PDB:5V8W"
SQ SEQUENCE 658 AA; 73814 MW; 81F1A24B99704684 CRC64;
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS NLPGWSLKDG
NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITEHTGFT
GTVYATEPTV QIGRLLMEEL VNFIERVPKA QSASLWKNKD IQRLLPSPLK DAVEVSTWRR
CYTMQEVNSA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS
SLLTTHPQPM DQASLKNSDV LVLTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY
PSGVIYDLLE CLYQYIDSAG LSSVPLYFIS PVANSSLEFS QIFAEWLCHN KQSKVYLPEP
PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL RFGDVVHFME LWGKSSLNTV
IFTEPDFSYL EALAPYQPLA MKCIYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP
AQSHRMDLMI DCQPPAMSYR RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV
SAVLHTKDNK HLLQPPPRPA QPTSGKKRKR VSDDVPDCKV LKPLLSGSIP VEQFVQTLEK
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EMLRVRLRDL VLKFLQKF
