ID   INT9_MACFA              Reviewed;         637 AA.
AC   Q4R5Z4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Integrator complex subunit 9;
DE            Short=Int9;
GN   Name=INTS9; ORFNames=QtsA-19691;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator (INT) complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC       3'-box-dependent processing. The Integrator complex is associated with
CC       the C-terminal domain (CTD) of RNA polymerase II largest subunit
CC       (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates
CC       recruitment of cytoplasmic dynein to the nuclear envelope, probably as
CC       component of the INT complex. {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts
CC       with ESRRB, ESRRB is probably not a core component of the multiprotein
CC       complex Integrator and this association is a bridge for the interaction
CC       with the multiprotein complex Integrator; attracts the transcriptional
CC       machinery (By similarity). {ECO:0000250|UniProtKB:Q8K114,
CC       ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- MISCELLANEOUS: Although strongly related to RNA-specific endonuclease
CC       proteins, it lacks the HXHXDH motif that binds zinc and participates in
CC       the catalytic center. Its function as endonuclease is therefore unsure.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB169398; BAE01481.1; -; mRNA.
DR   RefSeq; NP_001270778.1; NM_001283849.1.
DR   AlphaFoldDB; Q4R5Z4; -.
DR   SMR; Q4R5Z4; -.
DR   STRING; 9541.XP_005563022.1; -.
DR   GeneID; 101867367; -.
DR   CTD; 55756; -.
DR   eggNOG; KOG1138; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..637
FT                   /note="Integrator complex subunit 9"
FT                   /id="PRO_0000259558"
FT   REGION          527..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        58
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NV88"
SQ   SEQUENCE   637 AA;  71425 MW;  6F6164CE93DE87D7 CRC64;
     MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS SLPGWSLKDG
     NAFLDKTELI DLSTVDVILI SNYHCMMALP YITEHTGFTG TVYATEPTVQ IGRLLMEELV
     NFIERVPKAQ SASLWKNKDI QRLLPSPLKD AVEVSTWRRC YTMQEVNSAL SKIQLVGFSQ
     KIELFGAVQV TPLSSGYALG SSNWIIQSHY EKVSYVSGSS LLTTHPQPMD QASLKNSDVL
     VLTGLTQIPT ANPDGMVGEF CSNLALTVRN GGNVLVPCYP SGVIYDLLEC LYQYIDSAGL
     SSVPLYFISP VANSSLEFSQ IFAEWLCHNK QSKVYLPEPP FPHAELIQTN KLKHYPSIHG
     DFSNDFRQPC VVFTGHPSLR FGDVVHFMEL WGKSSLNTVI FTEPDFSYLE ALAPYQPLAM
     KCIYCPIDTR LNFIQVSKLL KEVQPLHVVC PEQYTQPPPA QSHRMDLMID CQPPAMSYRR
     AEVLALPFKR RYEKIEIMPE LADSLVPMEI KPGISLATVS AVLHTKDNKH LLQPPPRPAQ
     PTSGKKRKRV SDDVPDCKVL KPLLSGSIPV EQFVQTLEKH GFSDIKVEDT AKGHIVLLQE
     AETLIQIEED STHIICDNDE MLRVRLRDLV LKFLQKF