ID   INT9_NEMVE              Reviewed;         660 AA.
AC   A7SBF0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Integrator complex subunit 9 homolog;
GN   Name=ints9; ORFNames=v1g168629;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS469615; EDO39014.1; -; Genomic_DNA.
DR   RefSeq; XP_001631077.1; XM_001631027.1.
DR   AlphaFoldDB; A7SBF0; -.
DR   SMR; A7SBF0; -.
DR   STRING; 45351.EDO39014; -.
DR   EnsemblMetazoa; EDO39014; EDO39014; NEMVEDRAFT_v1g168629.
DR   GeneID; 5510608; -.
DR   KEGG; nve:5510608; -.
DR   eggNOG; KOG1138; Eukaryota.
DR   HOGENOM; CLU_023159_1_0_1; -.
DR   InParanoid; A7SBF0; -.
DR   OMA; CADSIKD; -.
DR   OrthoDB; 617493at2759; -.
DR   PhylomeDB; A7SBF0; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..660
FT                   /note="Integrator complex subunit 9 homolog"
FT                   /id="PRO_0000342372"
SQ   SEQUENCE   660 AA;  73577 MW;  C28314F60D7A237C CRC64;
     MKLYCVGHSV SSPCLVLQFK QTNIMLDCGL DMSTVNQFTP LSLVNNEKFS QLKSWSSREL
     QEIEGFTAQN NLKEAGGRLF IDAEPEVCPP ETGLIDFSMV DVILISNYHH MLALPFITEY
     SGFNGKIYAT EPTIQIGRDL MLELVTFAER VPKRRNGNMW KNDNVIRCLP APLNELANVK
     SWRVLYSKHD VKACISKIQA VSYSEKLDLC GILQLSAHSS GFCLGSSNWM LESEYEKISY
     LSPSSSFTTH PLPLNQTVLK NSDVLIITGV TEAPIDNPDA MLGEFCTHLA STLRAGGNVL
     VPCYPSGVLY DLFECLYTYL DNAKLGMVPI YFISPVADSS LAYSNIYGEW LCQSKQTKVY
     LPEPPFPHAE LLKEARLKVF SNLHNGFSSS FKTPCVVFTG HPSLRYGDAV HFMEIWGKSG
     NNTVIFTEPD FPYLEALAPY QPLAMKTCYC PIDPRLNFAQ ANKLLKELQP RHLVMPESYS
     RPPVIHPHRT DLTIEDPGCS LTTFNHLDVA ALPISRSFEK VVIANELSSC LHPQHVRPGV
     AVATLTGTLV TKDNKYTLQP LEFLVEPKAG SEGGDSSTNK GQLSRHLWGT VQLDDFVRSL
     KKRGITDVNV ESSGGEHTIH LPNDDAMILL DRGSTHIITH GNEELRIRIR DALLECVPQF