ID   INT9_XENLA              Reviewed;         658 AA.
AC   Q6DFF4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Integrator complex subunit 9;
DE            Short=Int9;
GN   Name=ints9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- MISCELLANEOUS: Although strongly related to RNA-specific endonuclease
CC       proteins, it lacks the HXHXDH motif that binds zinc and participates in
CC       the catalytic center. Its function as endonuclease is therefore unsure.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC076784; AAH76784.1; -; mRNA.
DR   RefSeq; NP_001086545.1; NM_001093076.1.
DR   AlphaFoldDB; Q6DFF4; -.
DR   SMR; Q6DFF4; -.
DR   MaxQB; Q6DFF4; -.
DR   PRIDE; Q6DFF4; -.
DR   DNASU; 446380; -.
DR   GeneID; 446380; -.
DR   KEGG; xla:446380; -.
DR   CTD; 446380; -.
DR   Xenbase; XB-GENE-6251479; ints9.S.
DR   OrthoDB; 617493at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 446380; Expressed in oocyte and 20 other tissues.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..658
FT                   /note="Integrator complex subunit 9"
FT                   /id="PRO_0000259561"
FT   REGION          547..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  74077 MW;  57D326EDC542D2E4 CRC64;
     MKLYCLSGHP TLPCNILKFK SSTIMLDCGL DMTSTLSFLP LPLVHSTRLS KLPGWVTKDG
     NNQFEKELKE CSGRVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITERTGFT
     GTVYATEPTV QIGRLLMEEL VNFIERVPKA QSATVWKHKD VQRLLPAPLK DAVEVFTWKK
     CYSMQEVNAA LSKIQLVGYS QKIELFGVVQ VTPLSSGYAL GSSNWVIQSH YEKVSYVSGS
     SLLTTHPQPM DQTSLKNSDV LILTGLTQIP TANPDGMVGE FCSNLAMTIR SGGNVLVPCY
     PSGVIYDLLE CLYQYIDSAG LSNVPFYFIS PVANSSLEFS QIFAEWLCHN KQNKVYLPEP
     PFPHAELIQS NKLKHYPNIH GDFSNDFKQP CVVFTGHPTL RFGDVVHFME LWGKSSLNTV
     IFTEPDFSYL DALAPYQPLA MKCVYCPIDT RLNFIQVTKL LKEVQPLHVV CPEQYTQPPA
     TQSHRSDLMI DCQPPPMSYH RAEVLTLPFK RRYEKIEIMP ELAQSLVPFE MKPGVSLATV
     SAVLHSKDNK HVLQPPPKPV APPGSKKRKR PAEESPETPP FKPLLSGSIP VEQFVQTLEK
     NGFSDVKIED TAKGHIVHLQ EAETLIQFEE DSTHIICEHD ERLRVRLRDL VLKFLQKF