ID   INTG_BPPF1              Reviewed;         333 AA.
AC   Q38067;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   02-DEC-2020, entry version 70.
DE   RecName: Full=Putative integrase;
OS   Pseudomonas phage Pf1 (Bacteriophage Pf1).
OC   Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes;
OC   Tubulavirales; Inoviridae; Primolicivirus.
OX   NCBI_TaxID=2011081;
OH   NCBI_TaxID=287; Pseudomonas aeruginosa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2010913; DOI=10.1016/0022-2836(91)90717-k;
RA   Hill D.F., Short N.J., Perham R.N., Petersen G.B.;
RT   "DNA sequence of the filamentous bacteriophage Pf1.";
RL   J. Mol. Biol. 218:349-364(1991).
CC   -!- FUNCTION: This protein may encode an integrase, which is necessary for
CC       integration of the viral DNA into host genome.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01246}.
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DR   EMBL; X52107; CAA36336.1; ALT_TERM; Genomic_DNA.
DR   PIR; S15148; S15148.
DR   SMR; Q38067; -.
DR   Proteomes; UP000002121; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Endonuclease; Hydrolase;
KW   Metal-binding; Nuclease; Reference proteome; Viral genome integration;
KW   Virus entry into host cell.
FT   CHAIN           1..333
FT                   /note="Putative integrase"
FT                   /id="PRO_0000378352"
FT   DOMAIN          48..133
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          155..317
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        193
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        216
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        269
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        272
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        295
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        304
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   333 AA;  38067 MW;  F44B4CAE490EEB2E CRC64;
     MTVRKDGKTW TADFYENGRS GRRIRKKGFA TKSAAIRYEQ DFFAVKGETG RPLDDRLSDL
     VKVWYDLHGC TLKDGKQRLA RCEALAKRLG NPLAFEFDSL AWARYRQRRL TEVKPETVNH
     EQRYLSAVFS ELIRLGSWHK ENPLGKVRQI KTDQVELTFL SLDQVARLLE ECKASTNNHT
     YPVALLCLAT GARWEEAESL TRGAVHGGKV HYHRIKNRQS RSVPIPDELE RLIFKVGMPG
     SGRLFMSCRA AFRCAYQRCG FQTPGQMTHI LRHTFASHYM MGGGDILTLQ RILGHSSITM
     TMRYAHLSPE HLASAMSLSP LYQIKHFASQ VHQ