ID   INTU_XENTR              Reviewed;         953 AA.
AC   F6U5F9;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein inturned;
DE   AltName: Full=Inturned planar cell polarity effector homolog;
GN   Name=intu;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Plays a role in the definition of cell polarity via the
CC       planar cell polarity (PCP) cascade. Required for ciliogenesis by
CC       controlling the organization of the apical actin cytoskeleton and the
CC       positioning of the basal bodies at the apical cell surface, which in
CC       turn is essential for the normal orientation of elongating ciliary
CC       microtubules. Proposed to function as core component of a functional
CC       module called CPLANE (ciliogenesis and planar polarity effectors)
CC       involved in recruitment of peripheral IFT-A proteins to basal bodies.
CC       Controls the localization of both rhoa and disheveled in multi-ciliated
CC       cells. Has an indirect effect on hedgehog signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q2I0E5}.
CC   -!- SUBUNIT: Interacts with fuz and wdpcp; fuz, intu and wdpcp probably
CC       form the core CPLANE (ciliogenesis and planar polarity effectors)
CC       complex. {ECO:0000250|UniProtKB:Q059U7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q059U7}. Cell
CC       surface {ECO:0000250|UniProtKB:Q2I0E5}. Cytoplasm, cytoskeleton, cilium
CC       basal body {ECO:0000250|UniProtKB:Q2I0E5}. Note=Enriched at the apical
CC       surface in ciliated cells. {ECO:0000250|UniProtKB:Q2I0E5}.
CC   -!- SIMILARITY: Belongs to the inturned family. {ECO:0000305}.
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DR   EMBL; AAMC01008054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01008055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01008056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002932089.1; XM_002932043.4.
DR   AlphaFoldDB; F6U5F9; -.
DR   PaxDb; F6U5F9; -.
DR   GeneID; 100495950; -.
DR   KEGG; xtr:100495950; -.
DR   CTD; 27152; -.
DR   Xenbase; XB-GENE-919872; intu.
DR   eggNOG; ENOG502QQJQ; Eukaryota.
DR   HOGENOM; CLU_014223_0_1_1; -.
DR   InParanoid; F6U5F9; -.
DR   OMA; WKEINNV; -.
DR   OrthoDB; 898612at2759; -.
DR   TreeFam; TF323932; -.
DR   Reactome; R-XTR-5610787; Hedgehog 'off' state.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0001736; P:establishment of planar polarity; IEA:InterPro.
DR   GO; GO:0060173; P:limb development; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR   InterPro; IPR043989; CCZ1/INTU/HSP4_longin_3.
DR   InterPro; IPR043988; CCZ1/INTU_longin_2.
DR   InterPro; IPR039151; INTU.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR21082; PTHR21082; 1.
DR   Pfam; PF19031; Intu_longin_1; 1.
DR   Pfam; PF19032; Intu_longin_2; 1.
DR   Pfam; PF19033; Intu_longin_3; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Developmental protein; Reference proteome.
FT   CHAIN           1..953
FT                   /note="Protein inturned"
FT                   /id="PRO_0000416286"
FT   DOMAIN          188..275
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  106422 MW;  382783CE8F3BE3CD CRC64;
     MDYTRGVSVE AAEEEEERRG WDSHSAGTCS SSYTDCSSCC SSDLEPEWLD RVQKNGELFY
     LELSEGEEEI LLPLSPLEPV GVNHVRFNDS EAEILSEERK NVGKNSEPRF RKLAKMLKKK
     HTSKKGSAGL NGPTCPTSIL KQHSSQKAGI IVRYQYRDTC LYVNPDRLPE GEPKEKSNLL
     QALIGIVHQS SRNSKRIERQ GSQEASQRLS NQEKLVVHGF IPGSPAIRCG QILIGDTLVA
     VNDVEVHVEN IERVLSCIPG PTQVKLTFET PVLCSGTALQ NQSTQVQTSI NDLAALVWGD
     EHANSQQDLQ RMSHIVMYLT LRLDSDTSKE EQEIIYQYPV SEASHKLKSI RGLFLTLSDM
     LQNVTGAPII SSSLILNDEL VHVSYWKEND KLLLISVPAQ RFPLLQLKNM TADIVRTLKF
     MYSTLDRAFC QAENISRLDH FFSLFFQRAL RVFSLTGIAG YGSQFYDACS SLLVENLPGV
     RWLSLPEDIK MEIDTVLSDL EALDFAELSE DFYEMRRLYM IIGTCLFYKG YLLSNHLPKE
     DLVDVAIYCR QYCLLTLASE RIGQLIIWRE VYPQYHLKQC GSSATEECTE PGGRYFLLIV
     GLRHFMLCTL LEAGGCTSKA TGHPGPDYIY VDQVKATLLQ LEMLDMSIED RLSSAPNPCL
     SCADWFLPST RDKLGNFTNS AVLSKLQTPP KKAPSPVSKR RLFAEAASSL RTRRPSPTRS
     SGGSDSGTDG AGESVGVVTH STPDMARKFG RRESLGSGGS DGSGGSGSLL KINKKKYSLP
     NPFSSGSLRK NLSERETDDI YNTIKLTSGP ENTLFHYLYF ETLQGVFISP THKEVEQLGG
     SIHPQLIKNF HRCCLSIHSV FQQALNQKNS KQSDSVACMD VAGFGPIKEH GVLFECSPEN
     WNDQKKSPPT MSYWVVGRLF MQPQPQELYV CFHDSVTEIS VELAFKLSFG MPL