ID   INTZ_ECOLI              Reviewed;         402 AA.
AC   P76542;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Prophage integrase IntZ {ECO:0000305};
DE   AltName: Full=Putative prophage CPZ-55 integrase;
GN   Name=intZ; OrderedLocusNames=b2442;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
CC   -!- FUNCTION: Integrase is necessary for integration of the phage into the
CC       host genome by site-specific recombination. In conjunction with
CC       excisionase, integrase is also necessary for excision of the prophage
CC       from the host genome.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; U00096; AAC75495.2; -; Genomic_DNA.
DR   PIR; A65019; A65019.
DR   RefSeq; NP_416937.2; NC_000913.3.
DR   RefSeq; WP_000047773.1; NZ_CP014272.1.
DR   AlphaFoldDB; P76542; -.
DR   SMR; P76542; -.
DR   DIP; DIP-10042N; -.
DR   STRING; 511145.b2442; -.
DR   PRIDE; P76542; -.
DR   EnsemblBacteria; AAC75495; AAC75495; b2442.
DR   GeneID; 946923; -.
DR   KEGG; eco:b2442; -.
DR   PATRIC; fig|511145.12.peg.2537; -.
DR   EchoBASE; EB3924; -.
DR   eggNOG; COG0582; Bacteria.
DR   InParanoid; P76542; -.
DR   OMA; LEIAMRI; -.
DR   PhylomeDB; P76542; -.
DR   BioCyc; EcoCyc:G7272-MON; -.
DR   PRO; PR:P76542; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   Gene3D; 3.30.160.390; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR038488; Integrase_DNA-bd_sf.
DR   InterPro; IPR025166; Integrase_DNA_bind_dom.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   Pfam; PF13356; Arm-DNA-bind_3; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Reference proteome;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..402
FT                   /note="Prophage integrase IntZ"
FT                   /id="PRO_0000197519"
FT   DOMAIN          103..183
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          206..381
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        244
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        271
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        332
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        335
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        359
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        368
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   402 AA;  45382 MW;  C43722D22B48F5DA CRC64;
     MSKTPLTAKA IDAAQPQDKP YKLTDSLTPG LFLLVHPNGS KYWRFRYWLN KREFLQAIGV
     YPLITLKEAR RRATESRSLI ANGINPVEQA RKEKAIDALN MAAGFKKVAE DWFATRVGGW
     SESYAKQVRS ALEKDVYPVL GKRSIVDITA RDVLALLQKK ERTAPEQARK LRRRIGEIFK
     FAVITELVTR NPVADLDTAL KARRPGHNAW IPISEIPAFY KALERAGSVQ IQTAIRLLIL
     TALRTAELRL CRWEWINLED ATITLPAEVM KARRPHVVPL SRQAVELLQD QFTRSGYSAF
     VFPGRFMDKP LSASAILKAL ERIGYKSIAT GHGWRTTFST ALNESGRYSP DWIEIQLAHV
     PKGIRGVYNQ AAYLKQRRAM MQDYADAIDS ILAGNGNPLE PE