ID   INVA_SALTI              Reviewed;         685 AA.
AC   P0A1I4; P35657; Q57033; Q57173; Q57186; Q57531;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Invasion protein InvA;
GN   Name=invA; OrderedLocusNames=STY3019, t2798;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in the invasion of the cells of the intestinal
CC       epithelium. Could be involved in the translocation of the InvE protein
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD06003.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70359.1; -; Genomic_DNA.
DR   RefSeq; NP_457290.1; NC_003198.1.
DR   RefSeq; WP_000927219.1; NZ_UCTX01000004.1.
DR   AlphaFoldDB; P0A1I4; -.
DR   SMR; P0A1I4; -.
DR   STRING; 220341.16503974; -.
DR   EnsemblBacteria; AAO70359; AAO70359; t2798.
DR   KEGG; stt:t2798; -.
DR   KEGG; sty:STY3019; -.
DR   PATRIC; fig|220341.7.peg.3073; -.
DR   eggNOG; COG4789; Bacteria.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   OMA; MGSFYIE; -.
DR   PHI-base; PHI:647; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   InterPro; IPR006302; T3SS_HrcV.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01399; hrcV; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..685
FT                   /note="Invasion protein InvA"
FT                   /id="PRO_0000190027"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   685 AA;  76055 MW;  5C293D9E4A69917E CRC64;
     MLLSLLNSAR LRPELLILVL MVMIISMFVI PLPTYLVDFL IALNIVLAIL VFMGSFYIDR
     ILSFSTFPAV LLITTLFRLA LSISTSRLIL IEADAGEIIA TFGQFVIGDS LAVGFVVFSI
     VTVVQFIVIT KGSERVAEVA ARFSLDGMPG KQMSIDADLK AGIIDADAAR ERRSVLERES
     QLYGSFDGAM KFIKGDAIAG IIIIFVNFIG GISVGMTRHG MDLSSALSTY TMLTIGDGLV
     AQIPALLIAI SAGFIVTRVN GDSDNMGRNI MTQLLNNPFV LVVTAILTIS MGTLPGFPLP
     VFVILSVVLS VLFYFKFREA KRSAAKPKTS KGEQPLSIEE KEGSSLGLIG DLDKVSTETV
     PLILLVPKSR REDLEKAQLA ERLRSQFFID YGVRLPEVLL RDGEGLDDNS IVLLINEIRV
     EQFTVYFDLM RVVNYSDEVV SFGINPTIHQ QGSSQYFWVT HEEGEKLREL GYVLRNALDE
     LYHCLAVTLA RNVNEYFGIQ ETKHMLDQLE AKFPDLLKEV LRHATVQRIS EVLQRLLSER
     VSVRNMKLIM EALALWAPRE KDVINLVEHI RGAMARYICH KFANGGELRA VMVSAEVEDV
     IRKGIRQTSG STFLSLDPEA SANLMDLITL KLDDLLIAHK DLVLLTSVDV RRFIKKMIEG
     RFPDLEVLSF GEIADSKSVN VIKTI