INVA_SALTY
ID INVA_SALTY Reviewed; 685 AA.
AC P0A1I3; P35657; Q57033; Q57173; Q57186; Q57531;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Invasion protein InvA;
GN Name=invA; OrderedLocusNames=STM2896;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SR-11;
RX PubMed=1624429; DOI=10.1128/jb.174.13.4338-4349.1992;
RA Galan J.E., Ginocchio C.C., Costeas P.;
RT "Molecular and functional characterization of the Salmonella invasion gene
RT invA: homology of InvA to members of a new protein family.";
RL J. Bacteriol. 174:4338-4349(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-656.
RC STRAIN=RKS2985, RKS2993, RKS2995, RKS3013, RKS3014, RKS3015, RKS3057,
RC RKS3333, and RKS4194;
RX PubMed=8975610; DOI=10.1128/aem.62.3.804-808.1996;
RA Boyd E.F., Wang F.-S., Whittam T.S., Selander R.K.;
RT "Molecular genetic relationships of the salmonellae.";
RL Appl. Environ. Microbiol. 62:804-808(1996).
CC -!- FUNCTION: Involved in the invasion of the cells of the intestinal
CC epithelium. Could be involved in the translocation of the InvE protein.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
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DR EMBL; M90846; AAA16867.1; -; Unassigned_DNA.
DR EMBL; AE006468; AAL21776.1; -; Genomic_DNA.
DR EMBL; U43237; AAC45021.1; -; Genomic_DNA.
DR EMBL; U43238; AAC45022.1; -; Genomic_DNA.
DR EMBL; U43239; AAC45023.1; -; Genomic_DNA.
DR EMBL; U43243; AAC45027.1; -; Genomic_DNA.
DR EMBL; U43244; AAC45028.1; -; Genomic_DNA.
DR EMBL; U43245; AAC45029.1; -; Genomic_DNA.
DR EMBL; U43246; AAC45030.1; -; Genomic_DNA.
DR EMBL; U43247; AAC45031.1; -; Genomic_DNA.
DR EMBL; U43248; AAC45032.1; -; Genomic_DNA.
DR PIR; A42888; A42888.
DR RefSeq; NP_461817.1; NC_003197.2.
DR RefSeq; WP_000927219.1; NC_003197.2.
DR PDB; 2X49; X-ray; 1.50 A; A=357-685.
DR PDB; 2X4A; X-ray; 2.54 A; A=357-685.
DR PDB; 3LW9; X-ray; 1.85 A; A/B=358-525.
DR PDBsum; 2X49; -.
DR PDBsum; 2X4A; -.
DR PDBsum; 3LW9; -.
DR AlphaFoldDB; P0A1I3; -.
DR SMR; P0A1I3; -.
DR DIP; DIP-59553N; -.
DR IntAct; P0A1I3; 9.
DR STRING; 99287.STM2896; -.
DR PaxDb; P0A1I3; -.
DR EnsemblBacteria; AAL21776; AAL21776; STM2896.
DR GeneID; 1254419; -.
DR KEGG; stm:STM2896; -.
DR PATRIC; fig|99287.12.peg.3052; -.
DR HOGENOM; CLU_015346_3_0_6; -.
DR OMA; MGSFYIE; -.
DR PhylomeDB; P0A1I3; -.
DR BioCyc; SENT99287:STM2896-MON; -.
DR EvolutionaryTrace; P0A1I3; -.
DR PHI-base; PHI:6464; -.
DR PHI-base; PHI:6588; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR InterPro; IPR006302; T3SS_HrcV.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01399; hrcV; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Virulence.
FT CHAIN 1..685
FT /note="Invasion protein InvA"
FT /id="PRO_0000190028"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 263
FT /note="S -> T (in strain: SR-11, RKS2985, RKS2993, RKS2995,
FT RKS3013, RKS3014, RKS3015, RKS3057, RKS3333 and RKS4194)"
FT VARIANT 306
FT /note="S -> A (in strain: RKS3013, RKS3014 and RKS3015)"
FT VARIANT 344
FT /note="S -> T (in strain: RKS2985, RKS2993, RKS2995,
FT RKS3013, RKS3014, RKS3015 and RKS3057)"
FT VARIANT 369
FT /note="S -> N (in strain: RKS3013, RKS3014 and RKS3015)"
FT VARIANT 381
FT /note="E -> D (in strain: RKS2985, RKS2993, RKS2995,
FT RKS3013, RKS3014, RKS3015 and RKS3057)"
FT VARIANT 404
FT /note="E -> D (in strain: RKS2995 and RKS3057)"
FT VARIANT 407
FT /note="D -> S (in strain: RKS3013, RKS3014 and RKS3015)"
FT VARIANT 412
FT /note="V -> I (in strain: RKS2995 and RKS3057)"
FT VARIANT 440
FT /note="V -> A (in strain: RKS2985, RKS2993, RKS2995,
FT RKS3013, RKS3014, RKS3015 and RKS3057)"
FT VARIANT 448..450
FT /note="IHQ -> TYH (in strain: RKS3013, RKS3014 and
FT RKS3015)"
FT VARIANT 448
FT /note="I -> T (in strain: RKS2985, RKS2993, RKS2995 and
FT RKS3057)"
FT VARIANT 475
FT /note="R -> Q (in strain: RKS3013, RKS3014 and RKS3015)"
FT VARIANT 489
FT /note="L -> V (in strain: SR-11, RKS2985, RKS2993, RKS2995,
FT RKS3057, RKS3333 and RKS4194)"
FT VARIANT 600
FT /note="V -> I (in strain: RKS2985 and RKS2993)"
FT VARIANT 617
FT /note="D -> E (in strain: RKS3013, RKS3014 and RKS3015)"
FT STRAND 362..366
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 368..370
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 371..376
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 379..391
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 398..402
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 410..415
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 418..424
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 429..432
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 438..441
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 447..451
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 454..459
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 461..468
FT /evidence="ECO:0007829|PDB:2X49"
FT TURN 469..471
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 474..476
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 477..491
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 493..495
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 499..510
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 514..521
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 526..537
FT /evidence="ECO:0007829|PDB:2X49"
FT TURN 538..540
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 546..556
FT /evidence="ECO:0007829|PDB:2X49"
FT TURN 557..559
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 563..573
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 575..583
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 588..593
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 595..604
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 605..607
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 612..614
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 618..632
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 639..641
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 643..646
FT /evidence="ECO:0007829|PDB:2X49"
FT TURN 648..650
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 651..658
FT /evidence="ECO:0007829|PDB:2X49"
FT TURN 659..661
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 666..669
FT /evidence="ECO:0007829|PDB:2X49"
FT HELIX 671..673
FT /evidence="ECO:0007829|PDB:2X49"
FT STRAND 679..685
FT /evidence="ECO:0007829|PDB:2X49"
SQ SEQUENCE 685 AA; 76055 MW; 5C293D9E4A69917E CRC64;
MLLSLLNSAR LRPELLILVL MVMIISMFVI PLPTYLVDFL IALNIVLAIL VFMGSFYIDR
ILSFSTFPAV LLITTLFRLA LSISTSRLIL IEADAGEIIA TFGQFVIGDS LAVGFVVFSI
VTVVQFIVIT KGSERVAEVA ARFSLDGMPG KQMSIDADLK AGIIDADAAR ERRSVLERES
QLYGSFDGAM KFIKGDAIAG IIIIFVNFIG GISVGMTRHG MDLSSALSTY TMLTIGDGLV
AQIPALLIAI SAGFIVTRVN GDSDNMGRNI MTQLLNNPFV LVVTAILTIS MGTLPGFPLP
VFVILSVVLS VLFYFKFREA KRSAAKPKTS KGEQPLSIEE KEGSSLGLIG DLDKVSTETV
PLILLVPKSR REDLEKAQLA ERLRSQFFID YGVRLPEVLL RDGEGLDDNS IVLLINEIRV
EQFTVYFDLM RVVNYSDEVV SFGINPTIHQ QGSSQYFWVT HEEGEKLREL GYVLRNALDE
LYHCLAVTLA RNVNEYFGIQ ETKHMLDQLE AKFPDLLKEV LRHATVQRIS EVLQRLLSER
VSVRNMKLIM EALALWAPRE KDVINLVEHI RGAMARYICH KFANGGELRA VMVSAEVEDV
IRKGIRQTSG STFLSLDPEA SANLMDLITL KLDDLLIAHK DLVLLTSVDV RRFIKKMIEG
RFPDLEVLSF GEIADSKSVN VIKTI
