ID   INVE_SALTI              Reviewed;         372 AA.
AC   Q56052; Q7C7M6; Q8Z490;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Invasion protein InvE;
GN   Name=invE; OrderedLocusNames=STY3020, t2799;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RKS3333;
RX   PubMed=8975610; DOI=10.1128/aem.62.3.804-808.1996;
RA   Boyd E.F., Wang F.-S., Whittam T.S., Selander R.K.;
RT   "Molecular genetic relationships of the salmonellae.";
RL   Appl. Environ. Microbiol. 62:804-808(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in the triggering of intracellular events that lead
CC       to microbial internalization. These events include increase in calcium
CC       level, redistribution of actin microfilaments, and changes in the
CC       normal structure of the microvilli. Encoded within the type III
CC       secretion system (SPI-1 TTSS), it is essential for the translocation of
CC       protein effectors into host cells. Forms a complex with SipB and SipC
CC       in the presence of their chaperone SicA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}. Note=Probably associated with a bacterial
CC       membrane-localized protein. {ECO:0000250}.
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DR   EMBL; U43274; AAC45058.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06004.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70360.1; -; Genomic_DNA.
DR   RefSeq; NP_457291.1; NC_003198.1.
DR   RefSeq; WP_000612166.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; Q56052; -.
DR   SMR; Q56052; -.
DR   STRING; 220341.16503975; -.
DR   EnsemblBacteria; AAO70360; AAO70360; t2799.
DR   KEGG; stt:t2799; -.
DR   KEGG; sty:STY3020; -.
DR   PATRIC; fig|220341.7.peg.3074; -.
DR   eggNOG; ENOG502ZABZ; Bacteria.
DR   HOGENOM; CLU_056140_1_0_6; -.
DR   OMA; YASMSML; -.
DR   PHI-base; PHI:648; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:InterPro.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050709; P:negative regulation of protein secretion; IEA:InterPro.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   InterPro; IPR010812; HrpJ-like.
DR   InterPro; IPR003520; Invas_InvE.
DR   InterPro; IPR013401; T3SS_LcrE.
DR   Pfam; PF07201; HrpJ; 1.
DR   PRINTS; PR01344; INVEPROTEIN.
DR   TIGRFAMs; TIGR02568; LcrE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Virulence.
FT   CHAIN           1..372
FT                   /note="Invasion protein InvE"
FT                   /id="PRO_0000084210"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         64
FT                   /note="Q -> E (in strain: RKS3333)"
FT   VARIANT         372
FT                   /note="S -> T (in strain: RKS3333)"
SQ   SEQUENCE   372 AA;  42391 MW;  2F02B4A6DFC8B393 CRC64;
     MIPGSTSGIS FSRILSRQAS HQDATQHTDA QQAEIQQAAE DSSPGAEVQK FVQSTDEMSA
     ALAQFRNRRD YEKKSSNLSN SFERVLEDEA LPKAKQILKL ISVHGGALED FLRQARSLFP
     DPSDLVLVLR ELLRRKDLEE IVRKKLESLL KHVEEQTDPK TLKAGINCAL KARLFGKTLS
     LKPGLLRASY RQFIQSESHE VEIYSDWIAS YGYQRRLVVL DFIEGSLLTD IDANDASCSR
     LEFGQLLRRL TQLKMLRSAD LLFVSTLLSY SFTKAFNAEE SSWLLLMLSL LQQPHEVDSL
     LADIIGLNAL LLSHKEHASF LQIFYQVCKA IPSSLFYEEY WQEELLMALR SMTDIAYKHE
     MAEQRRTIEK LS