INVE_SALTY
ID INVE_SALTY Reviewed; 372 AA.
AC P35671;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Invasion protein InvE;
GN Name=invE; OrderedLocusNames=STM2897;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=SR-11;
RX PubMed=1631083; DOI=10.1073/pnas.89.13.5976;
RA Ginocchio C., Pace J., Galan J.E.;
RT "Identification and molecular characterization of a Salmonella typhimurium
RT gene involved in triggering the internalization of salmonellae into
RT cultured epithelial cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:5976-5980(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
RC STRAIN=SR-11;
RX PubMed=7997169; DOI=10.1111/j.1365-2958.1994.tb00450.x;
RA Kaniga K., Bossio J.C., Galan J.E.;
RT "The Salmonella typhimurium invasion genes invF and invG encode homologues
RT of the AraC and PulD family of proteins.";
RL Mol. Microbiol. 13:555-568(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
RC STRAIN=TML;
RX PubMed=7868245; DOI=10.1128/iai.63.3.762-769.1995;
RA Lodge J., Douce G.R., Amin I.I., Bolton A.J., Martin G.D., Chatfield S.,
RA Dougan G., Brown N.L., Stephen J.;
RT "Biological and genetic characterization of TnphoA mutants of Salmonella
RT typhimurium TML in the context of gastroenteritis.";
RL Infect. Immun. 63:762-769(1995).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=SB300;
RX PubMed=12169593; DOI=10.1128/jb.184.17.4699-4708.2002;
RA Kubori T., Galan J.E.;
RT "Salmonella type III secretion-associated protein InvE controls
RT translocation of effector proteins into host cells.";
RL J. Bacteriol. 184:4699-4708(2002).
CC -!- FUNCTION: Involved in the triggering of intracellular events that lead
CC to microbial internalization. These events include increase in calcium
CC level, redistribution of actin microfilaments, and changes in the
CC normal structure of the microvilli. Encoded within the type III
CC secretion system (SPI-1 TTSS), it is essential for the translocation of
CC protein effectors into host cells. Forms a complex with SipB and SipC
CC in the presence of their chaperone SicA. Positively regulates the
CC secretion of SPI-1 TTSS effector proteins SipB, SipC and SipD and
CC negatively influences the secretion of SipA, SopA and SptP.
CC {ECO:0000269|PubMed:12169593, ECO:0000269|PubMed:1631083}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12169593};
CC Peripheral membrane protein {ECO:0000269|PubMed:12169593}.
CC Note=Probably associated with a bacterial membrane-localized protein.
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DR EMBL; M90714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE006468; AAL21777.1; -; Genomic_DNA.
DR EMBL; U08280; AAA74041.1; -; Genomic_DNA.
DR EMBL; X75302; CAA53050.2; -; Genomic_DNA.
DR PIR; A46138; A46138.
DR RefSeq; NP_461818.1; NC_003197.2.
DR RefSeq; WP_000612171.1; NC_003197.2.
DR AlphaFoldDB; P35671; -.
DR SMR; P35671; -.
DR STRING; 99287.STM2897; -.
DR PaxDb; P35671; -.
DR EnsemblBacteria; AAL21777; AAL21777; STM2897.
DR GeneID; 1254420; -.
DR KEGG; stm:STM2897; -.
DR PATRIC; fig|99287.12.peg.3053; -.
DR HOGENOM; CLU_056140_1_0_6; -.
DR OMA; YASMSML; -.
DR BioCyc; SENT99287:STM2897-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050709; P:negative regulation of protein secretion; IEA:InterPro.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR InterPro; IPR010812; HrpJ-like.
DR InterPro; IPR003520; Invas_InvE.
DR InterPro; IPR013401; T3SS_LcrE.
DR Pfam; PF07201; HrpJ; 1.
DR PRINTS; PR01344; INVEPROTEIN.
DR TIGRFAMs; TIGR02568; LcrE; 1.
PE 4: Predicted;
KW Cell membrane; Membrane; Reference proteome; Virulence.
FT CHAIN 1..372
FT /note="Invasion protein InvE"
FT /id="PRO_0000084211"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 64
FT /note="Q -> E (in Ref. 1; M90714 and 3; AAA74041)"
FT /evidence="ECO:0000305"
FT CONFLICT 117
FT /note="S -> T (in Ref. 1; M90714)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 42421 MW; 7E10B570D2AF644F CRC64;
MIPGSTSGIS FSRILSRQTS HQDATQHTDA QQAEIQQAAE DSSPGAEVQK FVQSTDEMSA
ALAQFRNRRD YEKKSSNLSN SFERVLEDEA LPKAKQILKL ISVHGGALED FLRQARSLFP
DPSDLVLVLR ELLRRKDLEE IVRKKLESLL KHVEEQTDPK TLKAGINCAL KARLFGKTLS
LKPGLLRASY RQFIQSESHE VEIYSDWIAS YGYQRRLVVL DFIEGSLLTD IDANDASCSR
LEFGQLLRRL TQLKMLRSAD LLFVSTLLSY SFTKAFNAEE SSWLLLMLSL LQQPHEVDSL
LADIIGLNAL LLSHKEHASF LQIFYQVCKA IPSSLFYEEY WQEELLMALR SMTDIAYKHE
MAEQRRTIEK LS
