INVF_SALTI
ID INVF_SALTI Reviewed; 216 AA.
AC P69342; P39437;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Invasion protein InvF;
DE AltName: Full=Transcriptional regulator InvF;
GN Name=invF; OrderedLocusNames=STY3022, t2801;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Transcriptional regulator required for the expression of
CC several genes encoding type III secretion system SPI1 effector
CC proteins. The interaction with SicA is necessary for the activation of
CC sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity).
CC {ECO:0000250}.
CC -!- INDUCTION: Transcriptionally activated by HilA. {ECO:0000250}.
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DR EMBL; AL513382; CAD06006.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70362.1; -; Genomic_DNA.
DR RefSeq; NP_457293.1; NC_003198.1.
DR RefSeq; WP_001674874.1; NZ_WSUR01000005.1.
DR AlphaFoldDB; P69342; -.
DR SMR; P69342; -.
DR STRING; 220341.16503977; -.
DR EnsemblBacteria; AAO70362; AAO70362; t2801.
DR KEGG; stt:t2801; -.
DR KEGG; sty:STY3022; -.
DR PATRIC; fig|220341.7.peg.3076; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_082966_1_0_6; -.
DR OMA; FSEGRHN; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation; Virulence.
FT CHAIN 1..216
FT /note="Invasion protein InvF"
FT /id="PRO_0000194526"
FT DOMAIN 112..210
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 129..150
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 177..200
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 216 AA; 24389 MW; 3F8153965D7FF0C7 CRC64;
MSFSESRHNE NCLIQEGALL FCEQAVVAPV SGDLVFRPLK IEVLSKLLAF IDGAGLVDTT
YAESDKWVLL SPEFRAIWQD RKRCEYWFLQ QIITPSPAFN KVLALLRKSE SYWLVGYLLA
QSTSGNTMRM LGEDYGVSYT HFRRLCSRAL GGKAKSELRN WRMAQSLLNS VEGHENITQL
AVNHGYSSPS HFSSEIKELI GVSPRKLSNI IQLADK
