INVF_SALTY
ID INVF_SALTY Reviewed; 216 AA.
AC P69343; P39437;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Invasion protein InvF;
DE AltName: Full=Transcriptional regulator InvF;
GN Name=invF; OrderedLocusNames=STM2899;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SR-11;
RX PubMed=7997169; DOI=10.1111/j.1365-2958.1994.tb00450.x;
RA Kaniga K., Bossio J.C., Galan J.E.;
RT "The Salmonella typhimurium invasion genes invF and invG encode homologues
RT of the AraC and PulD family of proteins.";
RL Mol. Microbiol. 13:555-568(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP FUNCTION IN REGULATION.
RC STRAIN=SL1344;
RX PubMed=10417179; DOI=10.1128/iai.67.8.4099-4105.1999;
RA Eichelberg K., Galan J.E.;
RT "Differential regulation of Salmonella typhimurium type III secreted
RT proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional
RT activators InvF and hilA.";
RL Infect. Immun. 67:4099-4105(1999).
RN [4]
RP FUNCTION.
RC STRAIN=SL1344;
RX PubMed=10438766; DOI=10.1128/jb.181.16.4949-4954.1999;
RA Darwin K.H., Miller V.L.;
RT "InvF is required for expression of genes encoding proteins secreted by the
RT SPI1 type III secretion apparatus in Salmonella typhimurium.";
RL J. Bacteriol. 181:4949-4954(1999).
RN [5]
RP FUNCTION, AND REGULATION BY HILA.
RC STRAIN=ATCC 14028s / SGSG 2262, LT2, and SL1344;
RX PubMed=10692170; DOI=10.1046/j.1365-2958.2000.01772.x;
RA Darwin K.H., Miller V.L.;
RT "The putative invasion protein chaperone SicA acts together with InvF to
RT activate the expression of Salmonella typhimurium virulence genes.";
RL Mol. Microbiol. 35:949-960(2000).
RN [6]
RP FUNCTION.
RC STRAIN=SL1344;
RX PubMed=11296219; DOI=10.1093/emboj/20.8.1850;
RA Darwin K.H., Miller V.L.;
RT "Type III secretion chaperone-dependent regulation: activation of virulence
RT genes by SicA and InvF in Salmonella typhimurium.";
RL EMBO J. 20:1850-1862(2001).
CC -!- FUNCTION: Transcriptional regulator required for the expression of
CC several genes encoding type III secretion system SPI1 effector
CC proteins. The interaction with SicA is necessary for the activation of
CC sigDE (sopB pipC), sicAsipBCDA, and sopE. {ECO:0000269|PubMed:10417179,
CC ECO:0000269|PubMed:10438766, ECO:0000269|PubMed:10692170,
CC ECO:0000269|PubMed:11296219}.
CC -!- INDUCTION: Transcriptionally activated by HilA.
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DR EMBL; U08280; AAA74039.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21779.1; -; Genomic_DNA.
DR PIR; S54419; S54419.
DR RefSeq; NP_461820.1; NC_003197.2.
DR RefSeq; WP_001674874.1; NC_003197.2.
DR AlphaFoldDB; P69343; -.
DR SMR; P69343; -.
DR STRING; 99287.STM2899; -.
DR PaxDb; P69343; -.
DR EnsemblBacteria; AAL21779; AAL21779; STM2899.
DR GeneID; 1254422; -.
DR KEGG; stm:STM2899; -.
DR PATRIC; fig|99287.12.peg.3055; -.
DR HOGENOM; CLU_082966_1_0_6; -.
DR OMA; FSEGRHN; -.
DR BioCyc; SENT99287:STM2899-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..216
FT /note="Invasion protein InvF"
FT /id="PRO_0000194527"
FT DOMAIN 112..210
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 129..150
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 177..200
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 216 AA; 24389 MW; 3F8153965D7FF0C7 CRC64;
MSFSESRHNE NCLIQEGALL FCEQAVVAPV SGDLVFRPLK IEVLSKLLAF IDGAGLVDTT
YAESDKWVLL SPEFRAIWQD RKRCEYWFLQ QIITPSPAFN KVLALLRKSE SYWLVGYLLA
QSTSGNTMRM LGEDYGVSYT HFRRLCSRAL GGKAKSELRN WRMAQSLLNS VEGHENITQL
AVNHGYSSPS HFSSEIKELI GVSPRKLSNI IQLADK
