ID   INVO_AOTTR              Reviewed;         544 AA.
AC   P24708;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Involucrin;
GN   Name=IVL;
OS   Aotus trivirgatus (Three-striped night monkey) (Douroucouli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=9505;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2507864; DOI=10.1093/oxfordjournals.molbev.a040563;
RA   Tseng H., Green H.;
RT   "The involucrin gene of the owl monkey: origin of the early region.";
RL   Mol. Biol. Evol. 6:460-468(1989).
CC   -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC       stratified squamous epithelia.
CC   -!- SUBUNIT: Directly or indirectly cross-linked to cornifelin (CNFN).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC       the cornified envelope.
CC   -!- TISSUE SPECIFICITY: Keratinocytes of epidermis and other stratified
CC       squamous epithelia.
CC   -!- PTM: Substrate of transglutaminase. Specific glutamines or lysines are
CC       cross-linked to keratins, desmoplakin and to inter involucrin
CC       molecules.
CC   -!- SIMILARITY: Belongs to the involucrin family. {ECO:0000305}.
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DR   EMBL; M25313; AAA35375.1; -; Genomic_DNA.
DR   PIR; I36911; I36911.
DR   AlphaFoldDB; P24708; -.
DR   GO; GO:0001533; C:cornified envelope; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0018149; P:peptide cross-linking; ISS:UniProtKB.
DR   GO; GO:0010224; P:response to UV-B; ISS:UniProtKB.
DR   InterPro; IPR019743; Involucrin_CS.
DR   InterPro; IPR019571; Involucrin_N.
DR   InterPro; IPR000354; Involucrin_rpt.
DR   Pfam; PF00904; Involucrin; 36.
DR   Pfam; PF10583; Involucrin_N; 1.
DR   PROSITE; PS00795; INVOLUCRIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Repeat.
FT   CHAIN           1..544
FT                   /note="Involucrin"
FT                   /id="PRO_0000159732"
FT   REGION          1..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..272
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..479
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  63926 MW;  2A02ABA5E1499F9D CRC64;
     MSQQHTLPVT LPPALSQELL DTVPPPVNTQ QEQRKQPAAL PPPCQEVPVE LPVEGPSKHE
     EKHMTIVKGA PEQECEQQQQ PQEQKLQQQH WEQDEEHQKA ENPEQQLKQE KAQREKQQLQ
     GQLEEEKKLL DQQPDHELAK SDEQLGTKKE QLLEFPEQQE GQLKCLEQQE GHLELPEQQE
     GQLKCLEQQE GHQELPEQQE GQLKHLEQQE GQLKHLEQQE GQVKHLEQQE KQSELPEQQR
     GQPKYLEQQE GQLKHLEEQK GQLKHLEHQE GQLELPEQVG QPKHLEQLEK QLEHPEQQEG
     QLKQLEEQEG QVKHLEQQEE QLKHLEQQEG QPKHPEQLEK QLEHPEQQEG QLKQLEEQEG
     QVKHLEQQEE QLKHLEQQEG QPKHLEQLEK QLEHLEQQEG QLKHLEQREE QLELPEQQVG
     QSKHLEQEEK QLEHPEQQEG QLKHLGKQEA QLELPEQVGQ PKHLEQQEKQ LEHPEQQEGQ
     LKPQEQQEGQ LKGLEQQERQ LEQPVFAPAP GQVQGIQQAL PPKGEVLLPV EQQQQKQEVQ
     WQHK