ID   INVO_CEBAL              Reviewed;         428 AA.
AC   P24709;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Involucrin;
GN   Name=IVL;
OS   Cebus albifrons (White-fronted capuchin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Cebinae; Cebus.
OX   NCBI_TaxID=9514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Esophageal fibroblast;
RX   PubMed=1766360; DOI=10.1093/oxfordjournals.molbev.a040674;
RA   Phillips M., Rice R.H., Djian P., Green H.;
RT   "The involucrin genes of the white-fronted capuchin and cottontop tamarin:
RT   the platyrrhine middle region.";
RL   Mol. Biol. Evol. 8:579-591(1991).
CC   -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC       stratified squamous epithelia.
CC   -!- SUBUNIT: Directly or indirectly cross-linked to cornifelin (CNFN).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC       the cornified envelope.
CC   -!- TISSUE SPECIFICITY: Keratinocytes of epidermis and other stratified
CC       squamous epithelia.
CC   -!- PTM: Substrate of transglutaminase. Specific glutamines or lysines are
CC       cross-linked to keratins, desmoplakin and to inter involucrin
CC       molecules.
CC   -!- SIMILARITY: Belongs to the involucrin family. {ECO:0000305}.
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DR   EMBL; M67478; AAA35405.1; -; Genomic_DNA.
DR   PIR; I36930; I36930.
DR   AlphaFoldDB; P24709; -.
DR   SMR; P24709; -.
DR   GO; GO:0001533; C:cornified envelope; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0018149; P:peptide cross-linking; ISS:UniProtKB.
DR   GO; GO:0010224; P:response to UV-B; ISS:UniProtKB.
DR   InterPro; IPR019743; Involucrin_CS.
DR   InterPro; IPR019571; Involucrin_N.
DR   InterPro; IPR000354; Involucrin_rpt.
DR   Pfam; PF00904; Involucrin; 22.
DR   Pfam; PF10583; Involucrin_N; 1.
DR   PROSITE; PS00795; INVOLUCRIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Repeat.
FT   CHAIN           1..428
FT                   /note="Involucrin"
FT                   /id="PRO_0000159734"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..293
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..333
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  50126 MW;  03AB71A5FC34E802 CRC64;
     MSQQHTLPVT LPPALSQELL NTVPPPINTQ QEQREQPVPL PPPCQKVPVE LPVEGPSKHE
     EKHVTIVKGV PEHECEQQQQ AQGQERQQQH WGQNKEHQKA GNPEQQLKQE EAQREKQQLQ
     GQLEEEKKLL DQQLDQELAK RDDQLGTKKK QLLEFPEQQE GQLKHLEQQE KPLELPEQQS
     GQPKYLEQQE GQLKHLEEQK GQLKHLEQQE GQLELPEQVD QPKHLEQLEK QLEHPEQQEG
     KLKKLEEEEE QLKHLEQQEE QLKHLEQQEG QLEHLEQQEG ELKHLEQCEG QLEHLEQQEG
     QLELPEQQVG QSKHLEQEEK QLEHPEQQEG QLKHLGKQEA QLELPEQVGQ PKHLEQQEKQ
     LEHPEQQEEQ QEGQLKDLEQ QERQLEQPVF APAPGQAQDI QQALPSKGEV LLPVDQQQQK
     QEVQWQQK