ID   INVO_PANPA              Reviewed;         560 AA.
AC   P14591;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Involucrin;
GN   Name=IVL;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2813403; DOI=10.1073/pnas.86.21.8447;
RA   Djian P., Green H.;
RT   "Vectorial expansion of the involucrin gene and the relatedness of the
RT   hominoids.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8447-8451(1989).
CC   -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC       stratified squamous epithelia.
CC   -!- SUBUNIT: Directly or indirectly cross-linked to cornifelin (CNFN).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC       the cornified envelope.
CC   -!- TISSUE SPECIFICITY: Keratinocytes of epidermis and other stratified
CC       squamous epithelia.
CC   -!- PTM: Substrate of transglutaminase. Specific glutamines or lysines are
CC       cross-linked to keratins, desmoplakin and to inter involucrin
CC       molecules.
CC   -!- SIMILARITY: Belongs to the involucrin family. {ECO:0000305}.
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DR   EMBL; M26514; AAA35422.1; -; Genomic_DNA.
DR   PIR; A40125; A40125.
DR   AlphaFoldDB; P14591; -.
DR   STRING; 9597.XP_003817249.1; -.
DR   eggNOG; ENOG502S84Y; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0001533; C:cornified envelope; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0018149; P:peptide cross-linking; ISS:UniProtKB.
DR   GO; GO:0010224; P:response to UV-B; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR002360; Involucrin.
DR   InterPro; IPR019743; Involucrin_CS.
DR   InterPro; IPR019571; Involucrin_N.
DR   InterPro; IPR000354; Involucrin_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR36910:SF9; PTHR36910:SF9; 2.
DR   Pfam; PF00904; Involucrin; 38.
DR   Pfam; PF10583; Involucrin_N; 1.
DR   PROSITE; PS00795; INVOLUCRIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..560
FT                   /note="Involucrin"
FT                   /id="PRO_0000159740"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..321
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  65478 MW;  E510287DBC35EAA4 CRC64;
     MSQQHTLPVT LSPALSQELL KTVPPPVNTQ QEQMKQPTPL PPPCQKMPVE LPVEVPSKQE
     EKHMTAVKGL PEQECEQQQQ EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKAQRDPQLN
     KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQRE GQLELPEQQE
     GQLKHLEQQK GQLELPEQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHQE GQLEVPEEQV
     GQLKYLEQQE GQLKHLDQQE KQPELPEQQV GQLKHLEQQE GQPKHLEQQK GQLEHLEEQE
     GQLKHLEQQE GQLEHLEHQE GQLGLPEQQV QQLKQLEKEE GQPKHLEEEE GQLKHLVQQE
     GQLEHLVQQE GQLEHLVQQE GQLEQQEGQV EHLEQQVEHL EQLGQLKHLE EQEGQLKHLE
     QQQGQLGVPE QVGQPKNLEQ EEKQLELPEQ QEGQLKHLEK QEAQLELPEQ QVGQPKHLEQ
     QEKQLEPPEQ QDGQLKHLEQ QEGQLKDLEQ QKGQLEQPVF APAPGQVQDI QSALPTKGEV
     LLPLEHQQQK QEVQWPPKHK