ID   INVO_PIG                Reviewed;         347 AA.
AC   P18175;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Involucrin;
GN   Name=IVL;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2385171; DOI=10.1093/oxfordjournals.molbev.a040609;
RA   Tseng H., Green H.;
RT   "The involucrin genes of pig and dog: comparison of their segments of
RT   repeats with those of prosimians and higher primates.";
RL   Mol. Biol. Evol. 7:293-302(1990).
CC   -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC       stratified squamous epithelia.
CC   -!- SUBUNIT: Directly or indirectly cross-linked to cornifelin (CNFN).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC       the cornified envelope.
CC   -!- TISSUE SPECIFICITY: Keratinocytes of epidermis and other stratified
CC       squamous epithelia.
CC   -!- PTM: Substrate of transglutaminase. Specific glutamines or lysines are
CC       cross-linked to keratins, desmoplakin and to inter involucrin
CC       molecules.
CC   -!- SIMILARITY: Belongs to the involucrin family. {ECO:0000305}.
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DR   EMBL; M34441; AAA31058.1; -; Genomic_DNA.
DR   PIR; I46592; I46592.
DR   RefSeq; NP_999613.1; NM_214448.1.
DR   AlphaFoldDB; P18175; -.
DR   STRING; 9823.ENSSSCP00000007032; -.
DR   PaxDb; P18175; -.
DR   GeneID; 407242; -.
DR   KEGG; ssc:407242; -.
DR   CTD; 3713; -.
DR   eggNOG; ENOG502S84Y; Eukaryota.
DR   InParanoid; P18175; -.
DR   OrthoDB; 1609954at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0001533; C:cornified envelope; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   InterPro; IPR009733; Involucrin2.
DR   InterPro; IPR019743; Involucrin_CS.
DR   InterPro; IPR019571; Involucrin_N.
DR   Pfam; PF06994; Involucrin2; 6.
DR   Pfam; PF10583; Involucrin_N; 1.
DR   PROSITE; PS00795; INVOLUCRIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..347
FT                   /note="Involucrin"
FT                   /id="PRO_0000159741"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  41408 MW;  3DE579871CF1C829 CRC64;
     MSQQYTLPVT LPPALSQEPL KPVSPPADTQ QEQVKQATPL PAPCQKMLSE LPVEVPLEDA
     EKHTTLVKGV PEQECEPQPQ EPQQQELHVE QQQQQQESQV QELHVDQQQQ QQESQEQELH
     VDQQQQQQES QEQELHVDQQ QQQESQVQEL HVGHHQQQQE SQEQELHVDH HQQQQESQEQ
     ELHVDQQQQQ QESQEQELHV DQQQQQQESQ EQELHVDHHQ QQQESQVQEL HVDHQQQQQE
     SQEQELHVDQ HQQQQESQEQ ELHVDQQQQE LQVQEVQQQQ QQQQEQQEDH QKAEHLEQEE
     AQREQQLKGQ LEQEKKGVYQ HLDQELTKRD EHLEKKGEHC WSSRRSL