INVO_PONPY
ID INVO_PONPY Reviewed; 835 AA.
AC P14708;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Involucrin;
GN Name=IVL;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2796727; DOI=10.1093/oxfordjournals.molbev.a040570;
RA Djian P., Green H.;
RT "The involucrin gene of the orangutan: generation of the late region as an
RT evolutionary trend in the hominoids.";
RL Mol. Biol. Evol. 6:469-477(1989).
CC -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC stratified squamous epithelia.
CC -!- SUBUNIT: Directly or indirectly cross-linked to cornifelin (CNFN).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC the cornified envelope.
CC -!- TISSUE SPECIFICITY: Keratinocytes of epidermis and other stratified
CC squamous epithelia.
CC -!- PTM: Substrate of transglutaminase. Specific glutamines or lysines are
CC cross-linked to keratins, desmoplakin and to inter involucrin
CC molecules.
CC -!- SIMILARITY: Belongs to the involucrin family. {ECO:0000305}.
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DR EMBL; M25312; AAA36935.1; -; Genomic_DNA.
DR PIR; I57441; I57441.
DR AlphaFoldDB; P14708; -.
DR GO; GO:0001533; C:cornified envelope; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; ISS:UniProtKB.
DR GO; GO:0018149; P:peptide cross-linking; ISS:UniProtKB.
DR GO; GO:0010224; P:response to UV-B; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR002360; Involucrin.
DR InterPro; IPR019743; Involucrin_CS.
DR InterPro; IPR019571; Involucrin_N.
DR InterPro; IPR000354; Involucrin_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR36910:SF9; PTHR36910:SF9; 7.
DR Pfam; PF00904; Involucrin; 65.
DR Pfam; PF10583; Involucrin_N; 1.
DR PROSITE; PS00795; INVOLUCRIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Repeat.
FT CHAIN 1..835
FT /note="Involucrin"
FT /id="PRO_0000159742"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 97977 MW; 2EE73E73E1EA41D4 CRC64;
MSQQHTLPVT LSPALSQELL KTVPPPVNTQ QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE
EKHMTAVKGL PEQECEQQQQ EPQEQELQQQ HWEQHEEHQK AENPEQQLKQ EKAQRDQQLN
EQLEEEKKLL DQRLDQELVK RDEQLGMKKE QLLELPEQQE QHLKHLEQQE GQLELPEQQE
GQLKHLEQQE GQLKHLEQQE GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLKHLDQQE
GQLKHLDQQE GQLKHLDQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHEE
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHQK
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHQE
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLKHLDQQE KQLELPEQQV GQLKHLEQQE
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLELPEQQE GQLKHLEQQE GQLKHLEHQE
GQLEVPEEQV GQLKYLEQQE GQLKHLDQQE GQLKHLDQQE KQLELPEQQV GQLKHLEQQE
GQLEHLEGQE GQLEHLEHQE GQLGLPEQQV WQLKQLEKQE GQPKNLEEEE GQLKHLVQQE
GQLEQQEGQV EHLEEQVGQL KHLEEQEGQL KYLEQQQGQL EVPEQQVGQP KHLEQEEKQL
ELPEQQEGQL KHLEKQEAQL ELPEQQVGQP KHLEQQEKQL EHPEQKDGQL KHLEQQEGQL
KNLEQQKGQL EQPVFAPAPG QVQDIQPALP TKGEVLLPVE QQQQKQEVQW PPKHK
