ID   INX10_CAEEL             Reviewed;         559 AA.
AC   Q22549;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Innexin-10;
DE   AltName: Full=Protein opu-10;
GN   Name=inx-10; Synonyms=opu-10; ORFNames=T18H9.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000250|UniProtKB:O61715}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; FO080648; CCD65454.1; -; Genomic_DNA.
DR   PIR; T29693; T29693.
DR   RefSeq; NP_001024139.1; NM_001028968.3.
DR   AlphaFoldDB; Q22549; -.
DR   SMR; Q22549; -.
DR   STRING; 6239.T18H9.5a; -.
DR   PaxDb; Q22549; -.
DR   EnsemblMetazoa; T18H9.5a.1; T18H9.5a.1; WBGene00002132.
DR   GeneID; 188580; -.
DR   KEGG; cel:CELE_T18H9.5; -.
DR   UCSC; T18H9.5a; c. elegans.
DR   CTD; 188580; -.
DR   WormBase; T18H9.5a; CE04973; WBGene00002132; inx-10.
DR   eggNOG; ENOG502QT3V; Eukaryota.
DR   InParanoid; Q22549; -.
DR   OMA; YIPIREV; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; Q22549; -.
DR   PRO; PR:Q22549; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00002132; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q22549; baseline and differential.
DR   GO; GO:0005921; C:gap junction; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..559
FT                   /note="Innexin-10"
FT                   /id="PRO_0000208511"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   REGION          488..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  65334 MW;  861DE0403FA4A3BD CRC64;
     MVLAAVLSML RYVGGSDDRD FVDRLHSYFT CNLLIGLAVL VSFKQFGGKP VECLVPDIFS
     SSWEQYAENY CWASDTYYVP TNEPVAGLQS DEKRQRKISY YQWVPFFLLL EAACFRLPSL
     LWKYLAGHSG IKINEIVKLS SDPNNIKPDI KRANIKSLTV HLQGALRFHR RLQKKQIRPH
     RFLWLFNLPY SAFFVTAMYL CTKFFYLANV CLQLMFMNRF LETDKYKWYG MGALVDLLNG
     TTWEQSGMFP RVSLCDFDVR VMGNMQEHTI QCVLVINIFN EKIFILLWFW YLALLVFTFG
     SFFYWLLVSL WRHLNVRFII RHLEMSDIAF DSSEDGAQEK VNRFISNYLK SDGVFVIRMM
     TLQSGVIFGT DLVQELWRNF HGSEPQLKRS NSAPKIEERE QWWPAYPSLV NPINPWRYRD
     ENQANALRWR RALGANVDNS IATQDLMEKL LPQNAHMRPS DDELLNRQPI AVQASYIDDE
     SDGKLKNEEK QNQQNATQPP YCYTNQNPTP YQNQNQIQNQ NQYSNYYRTP SLSRGTDSRP
     VSTATDTDQT KKQSMSTFK