ID   INX11_CAEEL             Reviewed;         465 AA.
AC   Q23157;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Innexin-11;
DE   AltName: Full=Protein opu-11;
GN   Name=inx-11; Synonyms=opu-11; ORFNames=W04D2.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000250|UniProtKB:O61715}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; Z75552; CAA99940.1; -; Genomic_DNA.
DR   PIR; T26146; T26146.
DR   RefSeq; NP_001256426.1; NM_001269497.1.
DR   AlphaFoldDB; Q23157; -.
DR   SMR; Q23157; -.
DR   EPD; Q23157; -.
DR   PaxDb; Q23157; -.
DR   EnsemblMetazoa; W04D2.3a.1; W04D2.3a.1; WBGene00002133.
DR   GeneID; 179710; -.
DR   UCSC; W04D2.3; c. elegans.
DR   CTD; 179710; -.
DR   WormBase; W04D2.3a; CE06538; WBGene00002133; inx-11.
DR   eggNOG; ENOG502QT3V; Eukaryota.
DR   HOGENOM; CLU_035763_0_2_1; -.
DR   InParanoid; Q23157; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; Q23157; -.
DR   PRO; PR:Q23157; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00002133; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q23157; baseline and differential.
DR   GO; GO:0005921; C:gap junction; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:1903763; F:gap junction channel activity involved in cell communication by electrical coupling; IEA:InterPro.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   InterPro; IPR031123; Innexin-11.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   PANTHER; PTHR11893:SF31; PTHR11893:SF31; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..465
FT                   /note="Innexin-11"
FT                   /id="PRO_0000208512"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   REGION          433..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   465 AA;  54576 MW;  467F2E009F721A43 CRC64;
     MVMIETFLGM AKYLSPREDD DWSDRLNYLM TPNILLAFSV LISFKQFGGR PIECMFPNKF
     PGSWEQYAEN YCWSQDTYFV EPTQDVSLLK KEERYTPDRQ LSYYQWVPFF LLLQAAFFRA
     PSYLWKYFSN HSGIRIHEVV EKAKDSANVE EEVREKNILI LKRHLSSALR FQANMERKKV
     QVHKTVTFLN FQYSSGFISW IYLFTKVLYF LNVFAQLYLM NYFLGTNRHH WYGFGVVQDI
     VQGEPWERSG YFPRAAVCDF EVRQVANIQR YSVQCVLVIN IFNEKIFVLL WFWYVILLLS
     STVSLVQWFI VLVFPCFSKW FVKQHLALST LQNFNQRNSR REDSDVSKFV TQYLHKDGVF
     VLRMVSSHAG IIFATDLVQA LYEAYDFQDK NKDVQGSPVS DDLQTISTGA ESSIRQRKTR
     KGSRIEYKAG FPISTSLMPD KDDIESSSTS SEEDQKRVSN VITNI