ID   INX14_CAEEL             Reviewed;         434 AA.
AC   O62136; Q19139;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Innexin-14;
DE   AltName: Full=Protein opu-14;
GN   Name=inx-14; Synonyms=opu-14; ORFNames=F07A5.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000250|UniProtKB:O61715}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=O62136-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=O62136-2; Sequence=VSP_002680;
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; Z72506; CAA96621.1; -; Genomic_DNA.
DR   EMBL; Z72506; CAA96618.1; -; Genomic_DNA.
DR   PIR; T20536; T20536.
DR   PIR; T20539; T20539.
DR   RefSeq; NP_492078.1; NM_059677.6. [O62136-1]
DR   RefSeq; NP_492079.1; NM_059678.5. [O62136-2]
DR   AlphaFoldDB; O62136; -.
DR   BioGRID; 37930; 5.
DR   DIP; DIP-24670N; -.
DR   IntAct; O62136; 1.
DR   STRING; 6239.F07A5.1b; -.
DR   TCDB; 1.A.25.1.6; the gap junction-forming innexin (innexin) family.
DR   EPD; O62136; -.
DR   PaxDb; O62136; -.
DR   PeptideAtlas; O62136; -.
DR   EnsemblMetazoa; F07A5.1a.1; F07A5.1a.1; WBGene00002136. [O62136-2]
DR   EnsemblMetazoa; F07A5.1a.2; F07A5.1a.2; WBGene00002136. [O62136-2]
DR   EnsemblMetazoa; F07A5.1b.1; F07A5.1b.1; WBGene00002136. [O62136-1]
DR   GeneID; 172488; -.
DR   KEGG; cel:CELE_F07A5.1; -.
DR   UCSC; F07A5.1b; c. elegans. [O62136-1]
DR   CTD; 172488; -.
DR   WormBase; F07A5.1a; CE05554; WBGene00002136; inx-14. [O62136-2]
DR   WormBase; F07A5.1b; CE17632; WBGene00002136; inx-14. [O62136-1]
DR   eggNOG; KOG3883; Eukaryota.
DR   InParanoid; O62136; -.
DR   OMA; YLCADGI; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; O62136; -.
DR   PRO; PR:O62136; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00002136; Expressed in germ line (C elegans) and 3 other tissues.
DR   GO; GO:0005921; C:gap junction; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0036093; P:germ cell proliferation; IMP:WormBase.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0001556; P:oocyte maturation; IMP:WormBase.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 2.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cell junction; Cell membrane; Gap junction;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..434
FT                   /note="Innexin-14"
FT                   /id="PRO_0000208514"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   VAR_SEQ         406..407
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002680"
SQ   SEQUENCE   434 AA;  50982 MW;  6EEC58DB8295134E CRC64;
     MIWEIPIIGD FITKPFKAAK LYEFYDRLHL FTVYLLGFFV LLTGAKQHFG NPIDCMLPKQ
     HDDLKSWRDY IHNFCLFYGT FRYDVSNGTS EFGSYTEDAS VNYYQWVPFF FAFQVCCFLL
     PFWCWAYMQK LIYIDMAFIV DYSGKINSEK TFEKTKEKVD RIVNYMHDHF KFRRAHKMGY
     LSWITFNSAF PSVLYSLTKL FFITNVIIQV NLVCKFLDVD SWTWGFDLLG KFIHPTPRAP
     EFSSFSDKQR FAAILTDGSY NRFQYFPILV GCEYQLQESV SNFVNHKAQC IIPMNVINEK
     IFIGLYFWLL VLTALSVIGT VKWILRIKSK KLNEVMIYKL IKKSLEREPF DSNIHDHRYN
     FVHKYLCADG ILLIYFMMDT NGFLKTEEVI GALFKKYCSD AGLEPLQTAP TLTSSPRDLA
     YSETNYGFAA PQKI