ID   INX16_CAEEL             Reviewed;         372 AA.
AC   O61787;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Innexin-16;
DE   AltName: Full=Protein opu-16;
GN   Name=inx-16; Synonyms=opu-16; ORFNames=R12E2.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RA   Peters M.A., Teramoto T., Iwasaki K., Jorgensen E.M.;
RT   "Innexin-16 is required for signals downstream of the defecation clock.";
RL   (In) Proceedings of the 15th international C. elegans meeting, pp.90-90,
RL   Los Angeles (2005).
CC   -!- FUNCTION: Structural component of the gap junctions (By similarity).
CC       Required for signals downstream of defecation clock (Ref.2).
CC       {ECO:0000250|UniProtKB:O61715, ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; FO080613; CCD65172.1; -; Genomic_DNA.
DR   PIR; T33091; T33091.
DR   RefSeq; NP_491314.1; NM_058913.4.
DR   AlphaFoldDB; O61787; -.
DR   SMR; O61787; -.
DR   BioGRID; 37476; 2.
DR   STRING; 6239.R12E2.5; -.
DR   iPTMnet; O61787; -.
DR   EPD; O61787; -.
DR   PaxDb; O61787; -.
DR   PeptideAtlas; O61787; -.
DR   EnsemblMetazoa; R12E2.5.1; R12E2.5.1; WBGene00002138.
DR   EnsemblMetazoa; R12E2.5.2; R12E2.5.2; WBGene00002138.
DR   GeneID; 172005; -.
DR   KEGG; cel:CELE_R12E2.5; -.
DR   UCSC; R12E2.5; c. elegans.
DR   CTD; 172005; -.
DR   WormBase; R12E2.5; CE28765; WBGene00002138; inx-16.
DR   eggNOG; ENOG502QWRS; Eukaryota.
DR   HOGENOM; CLU_035763_0_1_1; -.
DR   InParanoid; O61787; -.
DR   OMA; FAYFFCE; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; O61787; -.
DR   PRO; PR:O61787; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00002138; Expressed in larva and 3 other tissues.
DR   GO; GO:0005921; C:gap junction; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0019722; P:calcium-mediated signaling; IMP:WormBase.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:2000746; P:regulation of defecation rhythm; IMP:WormBase.
DR   GO; GO:1900073; P:regulation of neuromuscular synaptic transmission; IMP:WormBase.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Gap junction; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..372
FT                   /note="Innexin-16"
FT                   /id="PRO_0000208515"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   372 AA;  43086 MW;  FAACEA56A8A64DB3 CRC64;
     MSMLGNIKTY AQTVTSLSDN DDTSIDRLNY VVTTSILIAF SLLLFAKNYV GEPMQCWTPN
     QFAGGWESFA ESYCFIENTY FVPMQDSNLP AAETREGREM IYYQWVPFLL VIQALFFCVP
     RAFWIIYPSY SGLTIADMIT AARQNGKQLE GADEALEQVA MINWRTEQQK GHGSRIFNCY
     LVMKLLILLN IVLQFFLLNS FLNTAYTFWG WGIFWDMVNG RHWQESGHFP RVSFCDINVR
     ELGNIHHWSL QCVLMVNMFN EKIFIFLWFW FAFLLVATAG DFVIWVWRRF DSNSKLGFIL
     DLLNQEGIDH SPQKASELYK NVLRDDGVLF LRLLDSNSGR LNSEELMKKI YNISVGHATD
     LNTPIEEHAT SE