ID   INX17_CAEEL             Reviewed;         362 AA.
AC   O61788; Q2Z1N8; Q86S32;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Innexin-17;
DE   AltName: Full=Gap junction innexin;
DE   AltName: Full=Protein opu-17;
GN   Name=inx-17 {ECO:0000312|WormBase:R12E2.4b}; Synonyms=opu-17;
GN   ORFNames=R12E2.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAG50220.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   STRAIN=Bristol N2;
RA   Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y.,
RA   Thierry-Mieg D., Thierry-Mieg J.;
RT   "The Caenorhabditis elegans transcriptome project, a complementary view of
RT   the genome.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000250|UniProtKB:O61715}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=O61788-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=O61788-2; Sequence=VSP_016615, VSP_016616;
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; FO080613; CCD65170.1; -; Genomic_DNA.
DR   EMBL; FO080613; CCD65171.1; -; Genomic_DNA.
DR   EMBL; AF303262; AAG50220.1; -; mRNA.
DR   PIR; T33092; T33092.
DR   RefSeq; NP_001021592.1; NM_001026421.1. [O61788-2]
DR   RefSeq; NP_491315.1; NM_058914.3. [O61788-1]
DR   AlphaFoldDB; O61788; -.
DR   SMR; O61788; -.
DR   STRING; 6239.R12E2.4a; -.
DR   EPD; O61788; -.
DR   PaxDb; O61788; -.
DR   PeptideAtlas; O61788; -.
DR   PRIDE; O61788; -.
DR   EnsemblMetazoa; R12E2.4a.1; R12E2.4a.1; WBGene00002139. [O61788-1]
DR   EnsemblMetazoa; R12E2.4b.1; R12E2.4b.1; WBGene00002139. [O61788-2]
DR   GeneID; 172006; -.
DR   KEGG; cel:CELE_R12E2.4; -.
DR   UCSC; R12E2.4b; c. elegans. [O61788-1]
DR   CTD; 172006; -.
DR   WormBase; R12E2.4a; CE18136; WBGene00002139; inx-17. [O61788-1]
DR   WormBase; R12E2.4b; CE38537; WBGene00002139; inx-17. [O61788-2]
DR   eggNOG; ENOG502QWRS; Eukaryota.
DR   HOGENOM; CLU_035763_0_0_1; -.
DR   InParanoid; O61788; -.
DR   OMA; FCWIHTT; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; O61788; -.
DR   PRO; PR:O61788; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00002139; Expressed in larva and 3 other tissues.
DR   GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell junction; Cell membrane; Gap junction;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..362
FT                   /note="Innexin-17"
FT                   /id="PRO_0000208516"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   VAR_SEQ         261..266
FT                   /note="MFNEKL -> IRNFNS (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_016615"
FT   VAR_SEQ         267..362
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_016616"
SQ   SEQUENCE   362 AA;  42100 MW;  8A3360F299AA4398 CRC64;
     MKIDTGFYSK TITPTYDSDA IDRLRYYFTV FLLTSSAFFI MAKQYVGQSI QCWAPKQFKG
     GWEEYAESYC LIENTYYVHM NNSNLPGPAI RENKELKYYQ WVPFILFGLA VVIYIPRVIW
     NALQSLIGIN ISIVTSNLRK VAKSGFTSEN PDIEKKKKEM QCKKKATSRQ VDGEFWGSRL
     TTCILATKFL ATILIFISMG FLDYFMGLGP MYGWTITKDI LQGRQWQESG SFPRVTFCDF
     QVRELGYVNN WSLQCVLMVN MFNEKLFIAL WWWYALLAIL SIFDIFRVLF RFTIHHQISF
     ITRILACTGD SAISATEVGE FNRKVLRIDG INLTHLVYAN ATIFEAADFV RPMWEQFKEN
     QN