ID   INX19_CAEBR             Reviewed;         439 AA.
AC   A8WVX4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 3.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Innexin-19;
GN   Name=inx-19; ORFNames=CBG03987;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Structural component of the gap junctions that specifically
CC       coordinates left-right asymmetry in the developing nervous system. Acts
CC       by forming gap junction network linking embryonic neurons and providing
CC       electrical coupling between cells, leading to promote or inhibit AWC
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; HE600906; CAP24786.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WVX4; -.
DR   SMR; A8WVX4; -.
DR   STRING; 6238.CBG03987; -.
DR   WormBase; CBG03987; CBP47099; WBGene00026740; Cbr-inx-19.
DR   eggNOG; ENOG502SSX3; Eukaryota.
DR   HOGENOM; CLU_035763_0_1_1; -.
DR   InParanoid; A8WVX4; -.
DR   OMA; MFFHATL; -.
DR   OrthoDB; 738314at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Developmental protein; Differentiation;
KW   Gap junction; Ion channel; Ion transport; Membrane; Neurogenesis;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..439
FT                   /note="Innexin-19"
FT                   /id="PRO_0000341371"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
SQ   SEQUENCE   439 AA;  51368 MW;  22A5A0A079FD8E80 CRC64;
     MFFHATLARS FISALSVRGD DDAVDRLNYY YTPLILAVCC LVISAKQYGG TPIECWVNPH
     SRESMEEYIE SYCWIQNTYW IPMYENVPDD HTAREEKQIG YYQWVPFILI AEALMFSLPC
     IFWRLCSFQS GLNIQTLINA ACDAQALLDY SDRQKAVEAI TCNFVDNLDL QSPNGRIRAR
     GWIARIKFSR FLSGQCISIV YSFTKLLYSV NVVAQFFILN ACLKSSEFVF FGFQVLSDIW
     AGRPWTETGH FPRVTLCDFE VRYLANLNRY TVQCALLINI INEKVFAFLW CWYMILAIIT
     TCSFIYWIAN SFIHSEKVDY VMKFIQIAES SEYKKLQKFE KDATVERLYT VIAFAPHLLD
     SFVSDFLKSD GILMLRMISN HAGDMIVVQL VRNLWQEYRE RNWREFEEHE EMKDVEMRRI
     QGTRERIVIA NPGQTKSFL