INX19_CAEEL
ID INX19_CAEEL Reviewed; 454 AA.
AC O61715; Q86S34;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Innexin-19;
DE AltName: Full=Neuronal symmetry protein 5;
DE AltName: Full=Protein opu-19;
GN Name=inx-19; Synonyms=nsy-5, opu-19; ORFNames=T16H5.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NOMENCLATURE.
RX PubMed=9375655; DOI=10.1046/j.1471-4159.1997.69062251.x;
RA Barnes T.M., Hekimi S.;
RT "The C. elegans avermectin resistance and anesthetic response gene unc-9
RT encodes a member of a protein family implicated in electrical coupling of
RT excitable cells.";
RL J. Neurochem. 69:2251-2260(1997).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF GLU-70.
RX PubMed=17512411; DOI=10.1016/j.cell.2007.02.052;
RA Chuang C.-F., Vanhoven M.K., Fetter R.D., Verselis V.K., Bargmann C.I.;
RT "An innexin-dependent cell network establishes left-right neuronal
RT asymmetry in C. elegans.";
RL Cell 129:787-799(2007).
CC -!- FUNCTION: Structural component of the gap junctions that specifically
CC coordinates left-right asymmetry in the developing nervous system. Acts
CC by forming gap junction network linking embryonic neurons and providing
CC electrical coupling between cells, leading to promote or inhibit AWC
CC signaling. Required for the left and right AWC olfactory neurons to
CC establish asymmetric patterns of gene expression during embryogenesis.
CC Acts autonomously. {ECO:0000269|PubMed:17512411}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17512411};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351,
CC ECO:0000269|PubMed:17512411}. Cell junction, gap junction
CC {ECO:0000269|PubMed:17512411}. Note=Specifically present at the
CC transient gap junctions formed between the cell bodies of embryonic
CC neurons. Excluded from axons and dendrites.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O61715-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O61715-2; Sequence=VSP_034267;
CC -!- TISSUE SPECIFICITY: Specifically expressed in sensory neurons and
CC interneurons in the head and tail. Expressed in neurons AWC, ASH, AFD,
CC ASI, ADL, ASK, BAG, AWB, and ADF (head sensory neurons); ADA, AIZ, RIC,
CC AIY, and AIM (head interneurons); PHA and PHB (tail sensory neurons);
CC and PVC and PVQ (tail interneurons). {ECO:0000269|PubMed:17512411}.
CC -!- DEVELOPMENTAL STAGE: Expression begins about halfway through
CC embryogenesis. Expressed at higher level in late embryos and in L1
CC larvae, and fades thereafter. In adults, a weak expression is
CC maintained in several neurons, including ASH but not AWC.
CC {ECO:0000269|PubMed:17512411}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
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DR EMBL; FO081208; CCD69899.1; -; Genomic_DNA.
DR EMBL; FO081208; CCD69900.1; -; Genomic_DNA.
DR RefSeq; NP_490983.2; NM_058582.5. [O61715-1]
DR RefSeq; NP_871864.1; NM_182064.3.
DR AlphaFoldDB; O61715; -.
DR SMR; O61715; -.
DR STRING; 6239.T16H5.1a; -.
DR TCDB; 1.A.25.1.5; the gap junction-forming innexin (innexin) family.
DR PaxDb; O61715; -.
DR EnsemblMetazoa; T16H5.1a.1; T16H5.1a.1; WBGene00002141. [O61715-1]
DR EnsemblMetazoa; T16H5.1a.2; T16H5.1a.2; WBGene00002141. [O61715-1]
DR EnsemblMetazoa; T16H5.1b.1; T16H5.1b.1; WBGene00002141. [O61715-2]
DR GeneID; 171805; -.
DR KEGG; cel:CELE_T16H5.1; -.
DR UCSC; T16H5.1a; c. elegans. [O61715-1]
DR CTD; 171805; -.
DR WormBase; T16H5.1a; CE30834; WBGene00002141; inx-19. [O61715-1]
DR WormBase; T16H5.1b; CE33183; WBGene00002141; inx-19. [O61715-2]
DR eggNOG; ENOG502SSX3; Eukaryota.
DR InParanoid; O61715; -.
DR OMA; MFFHATL; -.
DR OrthoDB; 738314at2759; -.
DR PhylomeDB; O61715; -.
DR PRO; PR:O61715; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002141; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032809; C:neuronal cell body membrane; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0019855; F:calcium channel inhibitor activity; IGI:WormBase.
DR GO; GO:0005243; F:gap junction channel activity; IDA:UniProtKB.
DR GO; GO:0055077; F:gap junction hemi-channel activity; IDA:UniProtKB.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IGI:WormBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0035545; P:determination of left/right asymmetry in nervous system; IMP:WormBase.
DR GO; GO:0010496; P:intercellular transport; IDA:WormBase.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:2001258; P:negative regulation of cation channel activity; IGI:WormBase.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; PTHR11893; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Cell membrane; Developmental protein;
KW Differentiation; Gap junction; Ion channel; Ion transport; Membrane;
KW Neurogenesis; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..454
FT /note="Innexin-19"
FT /id="PRO_0000341372"
FT TOPO_DOM 1..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 70..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 140..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 236..300
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 322..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..16
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_034267"
FT MUTAGEN 70
FT /note="E->K: In ky634; absence of chemotaxis to the odorant
FT 2-butanone, which is sensed by AWC(ON), but normal response
FT to the odorant 2,3-pentanedione, which is sensed by
FT AWC(OFF), suggesting the absence of functional AWC(ON)
FT neurons."
FT /evidence="ECO:0000269|PubMed:17512411"
SQ SEQUENCE 454 AA; 52975 MW; E408BE61913358F2 CRC64;
MWRTPASTGP LRQDRQMFFH ATLARSFINA LSVRGDDDAV DRLNYYYTPL ILAVCCLVIS
AKQYGGTPIE CWVNPHSRES MEEYIESYCW IQNTYWIPMY ENVPDDHTAR EEKQIGYYQW
VPFILIAEAL MFSLPCIFWR LCSFQSGLNI QTLINAACDG QALLDASDRQ KAVEAITTNF
VDNLDLQSPN GRIRARGWIA RIKFSRFLSG QCLSILHSFT KLLYSMNVVA QFLILNACLK
SSDFLFFGFQ VLNDIWAGRP WTETGHFPRV TLCDFEVRYL ANLNRYTVQC ALLINIINEK
VFAFLWCWYM ILAIITTCSF IYWIANSFIH SEKVDYVMKF IQIAESSEFK KLQKFEKDAT
VERLYTVIAF APHLLDTFVS DFLKSDGVLM LRMISNHAGD MIVVQLVRNL WQEFRERNWR
EFEEHEEMKD VEMRRIHGGE RIVISNPGQT KSFL
