ID   INX1_SCHAM              Reviewed;         361 AA.
AC   Q9XYN0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Innexin inx1;
DE            Short=Innexin-1;
DE   AltName: Full=G-Inx1;
GN   Name=inx1;
OS   Schistocerca americana (American grasshopper).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Body wall, Embryo, and Ventral nerve cord;
RX   PubMed=10079517;
RX   DOI=10.1002/(sici)1520-6408(1999)24:1/2<137::aid-dvg13>3.0.co;2-7;
RA   Ganfornina M.D., Sanchez D., Herrera M., Bastiani M.J.;
RT   "Developmental expression and molecular characterization of two gap
RT   junction channel proteins expressed during embryogenesis in the grasshopper
RT   Schistocerca americana.";
RL   Dev. Genet. 24:137-150(1999).
CC   -!- FUNCTION: Structural components of the gap junctions.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction.
CC   -!- TISSUE SPECIFICITY: Expressed in embryonic neural precursors including
CC       the dorsal median neuroblast, glial cells, neuropilar glial ring,
CC       developing myoblasts cells and in a circumferential band of epithelial
CC       cells at the trochanter/coxa boundary stripe in the developing limb.
CC       {ECO:0000269|PubMed:10079517}.
CC   -!- DEVELOPMENTAL STAGE: Embryonic development.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; AF115853; AAD29305.1; -; mRNA.
DR   AlphaFoldDB; Q9XYN0; -.
DR   SMR; Q9XYN0; -.
DR   GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; TAS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..361
FT                   /note="Innexin inx1"
FT                   /id="PRO_0000208495"
FT   TOPO_DOM        1..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        50..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        131..181
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        203..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        289..361
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   361 AA;  41879 MW;  75EC5C61951059E7 CRC64;
     MYKLLGGLKE YLKWQDIVTD NAIFRLHNLF TTVLLLTCSL IITATQYVGN PIHCIVNGLP
     VRPINTYCWI TSTFTMPDAF LRQVGSEVAH PGVANDFGDE DAKKYYTYYQ WVCFVLFFQA
     MLCYTPKWIW DSIEGGLLRT LIMGLNRGLC QDDEKCMKKK ALIEYLLRHI KRHNMYALKY
     WFCETLCLVN IIGQLYLMNH FFDGEFFSYG LRVVAFSEQS QEERVDPMVY VFPRVTKCTF
     HKYGASGSIQ KHDSLCVLPL NIVNEKTYIF LWFWYIILAA LLSVLVVYRA VILAVPSVRP
     ILLHARNRMV PKEVTNAICR KTDVGDWWIL YMLGRNMDPM IYGEVIADLA KKIETPSSNN
     P