ID   INX2_SCHAM              Reviewed;         359 AA.
AC   Q9XYN1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Innexin inx2;
DE            Short=Innexin-2;
DE   AltName: Full=G-Inx2;
GN   Name=inx2;
OS   Schistocerca americana (American grasshopper).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Body wall, Embryo, and Ventral nerve cord;
RX   PubMed=10079517;
RX   DOI=10.1002/(sici)1520-6408(1999)24:1/2<137::aid-dvg13>3.0.co;2-7;
RA   Ganfornina M.D., Sanchez D., Herrera M., Bastiani M.J.;
RT   "Developmental expression and molecular characterization of two gap
RT   junction channel proteins expressed during embryogenesis in the grasshopper
RT   Schistocerca americana.";
RL   Dev. Genet. 24:137-150(1999).
CC   -!- FUNCTION: Structural components of the gap junctions.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction.
CC   -!- TISSUE SPECIFICITY: Widespread expression in embryo, in anterior and
CC       posterior row of neural precursors, midline precursors and in
CC       epithelial sheet of stomodeum. {ECO:0000269|PubMed:10079517}.
CC   -!- DEVELOPMENTAL STAGE: Embryonic development.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; AF115854; AAD29306.1; -; mRNA.
DR   AlphaFoldDB; Q9XYN1; -.
DR   SMR; Q9XYN1; -.
DR   GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; TAS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..359
FT                   /note="Innexin inx2"
FT                   /id="PRO_0000208497"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        44..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        131..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        202..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TOPO_DOM        288..359
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   359 AA;  41446 MW;  9C313EEFDF14F1EE CRC64;
     MFDVFGSVKG LLKLDSVCID NNLFRLHYKA TVIILIAFSL LVTSRQYIGD PIDCIVDEIP
     LAVMDTYCWI YSTFTIPNRL NGKIGLEVAH PGVGAHVAGK DEVKYHKYYQ WVCFVLFFQA
     ILFYIPRYLW KTWEGGRIKM LVLDLNSPVV NEQSKADRKK LLVDYFATNL HTQNFYAYRF
     FICEALNFVN VVGQIYFMDL FLDGEFTTYG SDVVRFTEME PEERSDPMSR VFPKVTKCTF
     HKYGPSGSVQ TFDGLCVLPL NIVNEKIYVF LWFWFVILSV LTGIGLVYRL ATAMGPQMRM
     YLLRARSRLA PQDQIETISN KCQIGDWFVL YQLGKNIDPL IYKELVADLA KKLEGKEIV