INX5_CAEEL
ID INX5_CAEEL Reviewed; 447 AA.
AC Q23027;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Innexin-5;
DE AltName: Full=Protein opu-5;
GN Name=inx-5; Synonyms=opu-5; ORFNames=R09F10.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Structural component of the gap junctions.
CC {ECO:0000250|UniProtKB:O61715}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
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DR EMBL; FO081137; CCD69417.1; -; Genomic_DNA.
DR PIR; G89587; G89587.
DR RefSeq; NP_509403.2; NM_077002.3.
DR AlphaFoldDB; Q23027; -.
DR SMR; Q23027; -.
DR STRING; 6239.R09F10.4; -.
DR iPTMnet; Q23027; -.
DR EPD; Q23027; -.
DR PaxDb; Q23027; -.
DR PeptideAtlas; Q23027; -.
DR EnsemblMetazoa; R09F10.4.1; R09F10.4.1; WBGene00002127.
DR GeneID; 181086; -.
DR KEGG; cel:CELE_R09F10.4; -.
DR UCSC; R09F10.4; c. elegans.
DR CTD; 181086; -.
DR WormBase; R09F10.4; CE33811; WBGene00002127; inx-5.
DR eggNOG; ENOG502QWRS; Eukaryota.
DR HOGENOM; CLU_035763_0_1_1; -.
DR InParanoid; Q23027; -.
DR OMA; WEKYAET; -.
DR OrthoDB; 738314at2759; -.
DR PhylomeDB; Q23027; -.
DR PRO; PR:Q23027; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002127; Expressed in larva and 3 other tissues.
DR GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; PTHR11893; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..447
FT /note="Innexin-5"
FT /id="PRO_0000208507"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT REGION 389..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 51147 MW; F2CCDD5163D55594 CRC64;
MIGVLLPYVR KFQRSAESND IADRFSYQYT STLLGFSAIM MAASQYVGRP IQCWVPAQFT
RTWEKYAETY CFIKGTYFLP GAFASEGEMS VTSPDDAVTA TPQVGYYQWI PIVLVLQAFL
FYLPSIIWRT FNESCELKIK ELAAVSEASR KIKSNMSDDQ VKATKFGRYF FKKLNFRNES
PVFKETGSVV ASGKFLPALY LLVKILYLAN IVLQFWILTY FLETKSWMWG WQTFQDLMAG
REWETTGIFP RVTMCDFSIM DLTSVHDHSI QCVIVINMLA EKVYVFFWFW LLFVGLLTVC
SLAYWAVIYM LQSVGRNFIY SYLQQTPEFQ TEQERGSFVP ANFVDKCLTP DGVFISRLVQ
QNSGDLFTSI MLGEMFSLYR AREAEKAHKK DDDSALPASA PVDLQEDDDD DTPFPPPTKA
VAETLTSDDE EEETDVDSPD TTATLPR
