INX6_DROME
ID INX6_DROME Reviewed; 481 AA.
AC Q9VR82; Q9UA15;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Innexin inx6;
DE Short=Innexin-6;
DE AltName: Full=Gap junction protein prp6;
DE AltName: Full=Pas-related protein 6;
GN Name=Inx6; Synonyms=prp6; ORFNames=CG17063;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11960713; DOI=10.1016/s0925-4773(02)00025-4;
RA Stebbings L.A., Todman M.G., Phillips R., Greer C.E., Tam J., Phelan P.,
RA Jacobs K., Bacon J.P., Davies J.A.;
RT "Gap junctions in Drosophila: developmental expression of the entire
RT innexin gene family.";
RL Mech. Dev. 113:197-205(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 228-431.
RC TISSUE=Head;
RX PubMed=10352230; DOI=10.1016/s0378-1119(99)00123-7;
RA Curtin K.D., Zhang Z., Wyman R.J.;
RT "Drosophila has several genes for gap junction proteins.";
RL Gene 232:191-201(1999).
CC -!- FUNCTION: Structural components of the gap junctions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC junction {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Uniform expression in the imaginal wing disk.
CC Expressed in an outer layer of the pupal developing CNS. Also expressed
CC in pupal retina: cone cells and primary pigment cells.
CC {ECO:0000269|PubMed:11960713}.
CC -!- DEVELOPMENTAL STAGE: Not expressed in embryos. Expressed in larvae and
CC pupae. {ECO:0000269|PubMed:11960713}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD50380.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY057373; AAL25821.1; -; mRNA.
DR EMBL; AE014298; AAF50922.1; -; Genomic_DNA.
DR EMBL; AF137271; AAD50380.1; ALT_FRAME; mRNA.
DR RefSeq; NP_572374.1; NM_132146.2.
DR AlphaFoldDB; Q9VR82; -.
DR STRING; 7227.FBpp0077031; -.
DR PaxDb; Q9VR82; -.
DR EnsemblMetazoa; FBtr0077339; FBpp0077031; FBgn0027107.
DR GeneID; 31645; -.
DR KEGG; dme:Dmel_CG17063; -.
DR CTD; 31645; -.
DR FlyBase; FBgn0027107; Inx6.
DR VEuPathDB; VectorBase:FBgn0027107; -.
DR eggNOG; ENOG502QR27; Eukaryota.
DR GeneTree; ENSGT00530000064205; -.
DR HOGENOM; CLU_035763_1_1_1; -.
DR InParanoid; Q9VR82; -.
DR OMA; NFWLMDV; -.
DR OrthoDB; 738314at2759; -.
DR PhylomeDB; Q9VR82; -.
DR BioGRID-ORCS; 31645; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31645; -.
DR PRO; PR:Q9VR82; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0027107; Expressed in testis and 1 other tissue.
DR Genevisible; Q9VR82; DM.
DR GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0010496; P:intercellular transport; ISS:FlyBase.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0072375; P:medium-term memory; IMP:FlyBase.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; PTHR11893; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..481
FT /note="Innexin inx6"
FT /id="PRO_0000208502"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 43..144
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 166..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 242..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 324..481
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 418
FT /note="S -> T (in Ref. 4; AAD50380)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="S -> R (in Ref. 4; AAD50380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 481 AA; 55661 MW; A435A51566B83013 CRC64;
MYAAVKPLSN YLRLKTVRIY DPIFTLHSKC TIVILLTCTF LLSAKQYFGE PILCLSSERQ
ADYVQSYCWT MGTYILPAEV DRDGGSSWEY ALYAPTSTAA ETFNVSSLRA LVAQNEQYAR
FISIAEGVGP ETRGVTKRMY LRYYQWVFMI LLFQSLLFYF PSFLWKVWEG QRMEQLCCEV
GDALIVEATY RTRLQMLTRY FRAQFAPIHW CYSIKYAFCE LLNVFISILN FWLMDVVFNG
FWYKYIHALA AIPVYDWNLW NLMTSRVFPK VAKCEMFVYG PSGTPNIMDI LCVLPLNILN
EKIFAVLYVW FLFIALLAIM NILYRLLVIC CPELRLQLLR THLNGMPKSH VREVLASAGY
GDWFVLMCVS INVNPTLFRE LLEQLYAKLN QARCTEPVFA EQPCQQVPQL AQVPQLFSHA
KLDRCPSRNC SLLIDPTADR HSICTESSHR VTAMPTAPTL NLMAPNDEII SMDRFFHESH
A
