ID   INX8_CAEEL              Reviewed;         382 AA.
AC   Q23593;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Innexin-8;
DE   AltName: Full=Protein opu-8;
GN   Name=inx-8; Synonyms=opu-8; ORFNames=ZK792.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000250|UniProtKB:O61715}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; Z68302; CAA92633.2; -; Genomic_DNA.
DR   PIR; T27993; T27993.
DR   RefSeq; NP_502209.1; NM_069808.4.
DR   AlphaFoldDB; Q23593; -.
DR   SMR; Q23593; -.
DR   BioGRID; 43196; 3.
DR   IntAct; Q23593; 2.
DR   STRING; 6239.ZK792.2.3; -.
DR   EPD; Q23593; -.
DR   PaxDb; Q23593; -.
DR   PeptideAtlas; Q23593; -.
DR   PRIDE; Q23593; -.
DR   EnsemblMetazoa; ZK792.2.1; ZK792.2.1; WBGene00002130.
DR   GeneID; 178101; -.
DR   KEGG; cel:CELE_ZK792.2; -.
DR   UCSC; ZK792.2.1; c. elegans.
DR   CTD; 178101; -.
DR   WormBase; ZK792.2; CE27419; WBGene00002130; inx-8.
DR   eggNOG; KOG3883; Eukaryota.
DR   GeneTree; ENSGT00940000174424; -.
DR   HOGENOM; CLU_035763_0_1_1; -.
DR   InParanoid; Q23593; -.
DR   OMA; DIPEYHK; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; Q23593; -.
DR   PRO; PR:Q23593; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00002130; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0005921; C:gap junction; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0036093; P:germ cell proliferation; IGI:WormBase.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..382
FT                   /note="Innexin-8"
FT                   /id="PRO_0000208510"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
SQ   SEQUENCE   382 AA;  44541 MW;  8807F0FEAD309A4F CRC64;
     MFSVPFLTSL TSHLGITAID DASDTLSCLI TAFLFITAAI LTSAKTYVGS AMECWLPQTY
     SGDWGEFAEN YCFLKDTYFY PRQQSMTDIP MYHKERHRLT YYQWSSMYLA VAGIAFMIPK
     FLWRLSQSTT DMPVVYFCDT ANEIKNETED KRSAKIKEMA RFMRTKITSV HTPSLFSFIR
     MYMVYSVIKI LYLVNAIAQF VIIAIFLGQK RNLFWGWTLF MNLLNGITWE TTGLFPRVTF
     CDFQVREMAG NNRDETVECV IGINEFNEKI FLFFWFWLVF LVFSTLIAHF YNAAQIVKPY
     FIHSLLFAIR DHDIVDQKEL FREFGEKYLT MDGKLILSFV KSQSDLVASE VAVEMYSDFL
     EARDRANIAE DKYNNILKNG KQ