INY2B_HUMAN
ID INY2B_HUMAN Reviewed; 535 AA.
AC A6NMK8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein INSYN2B {ECO:0000305};
DE AltName: Full=Inhibitory synaptic factor family member 2B {ECO:0000312|HGNC:HGNC:37271};
GN Name=INSYN2B {ECO:0000312|HGNC:HGNC:37271}; Synonyms=C5orf57, FAM196B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-524.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SIMILARITY: Belongs to the INSYN2 family. {ECO:0000305}.
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DR EMBL; AC008449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK055998; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS47336.1; -.
DR RefSeq; NP_001123363.1; NM_001129891.2.
DR RefSeq; NP_001333233.1; NM_001346304.1.
DR AlphaFoldDB; A6NMK8; -.
DR SMR; A6NMK8; -.
DR BioGRID; 935549; 1.
DR STRING; 9606.ENSP00000366582; -.
DR iPTMnet; A6NMK8; -.
DR PhosphoSitePlus; A6NMK8; -.
DR BioMuta; FAM196B; -.
DR MassIVE; A6NMK8; -.
DR PaxDb; A6NMK8; -.
DR PeptideAtlas; A6NMK8; -.
DR PRIDE; A6NMK8; -.
DR Antibodypedia; 64201; 10 antibodies from 6 providers.
DR DNASU; 100131897; -.
DR Ensembl; ENST00000377365.4; ENSP00000366582.3; ENSG00000204767.4.
DR GeneID; 100131897; -.
DR KEGG; hsa:100131897; -.
DR MANE-Select; ENST00000377365.4; ENSP00000366582.3; NM_001129891.3; NP_001123363.1.
DR UCSC; uc003mag.3; human.
DR CTD; 100131897; -.
DR DisGeNET; 100131897; -.
DR GeneCards; INSYN2B; -.
DR HGNC; HGNC:37271; INSYN2B.
DR HPA; ENSG00000204767; Tissue enhanced (brain, breast, salivary gland).
DR neXtProt; NX_A6NMK8; -.
DR OpenTargets; ENSG00000204767; -.
DR PharmGKB; PA165660363; -.
DR VEuPathDB; HostDB:ENSG00000204767; -.
DR eggNOG; ENOG502QT66; Eukaryota.
DR GeneTree; ENSGT00530000063787; -.
DR HOGENOM; CLU_543970_0_0_1; -.
DR InParanoid; A6NMK8; -.
DR OMA; DIYHSPS; -.
DR OrthoDB; 520296at2759; -.
DR PhylomeDB; A6NMK8; -.
DR TreeFam; TF333465; -.
DR PathwayCommons; A6NMK8; -.
DR SignaLink; A6NMK8; -.
DR BioGRID-ORCS; 100131897; 7 hits in 1069 CRISPR screens.
DR ChiTaRS; FAM196B; human.
DR GenomeRNAi; 100131897; -.
DR Pharos; A6NMK8; Tdark.
DR PRO; PR:A6NMK8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A6NMK8; protein.
DR Bgee; ENSG00000204767; Expressed in stromal cell of endometrium and 99 other tissues.
DR InterPro; IPR029337; INSYN2.
DR PANTHER; PTHR28682; PTHR28682; 1.
DR Pfam; PF15265; FAM196; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..535
FT /note="Protein INSYN2B"
FT /id="PRO_0000349183"
FT REGION 24..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..448
FT /evidence="ECO:0000255"
FT COMPBIAS 24..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 230
FT /note="S -> R (in Ref. 2; AK055998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 535 AA; 59204 MW; EE9F3BE78916F2FF CRC64;
MAQQNMKVRP VLLKRNSLES VEFVKQPHHR RSKSQQVRFK EDGTTKNPTG LAEVDVQTPE
DPAVMGKTQA TRHHLPPTYS LSFPRSQKAG GFRNIAIQTS PSLRKHFPVF KRKRLTASKS
LVEMPTASQS AIQVNGNLSE QDIVSSDLAY LRLAQHLEDG PRRVKVSHAF LPRVPKVQSN
GPVSICLEAG TWRSLEKATA AIQVPDDIYH SPSWEARESA LSPDRSAEVS NSIHPLDDTR
PGDGRRVTPL DSEKSTSCLN ATSVASHTPG TEELKPELLL PKDNSDDKDL GSLSSQSKET
CVPSSPRTHS SPSQGSHSQP AHPGRASDCP SSSNNHQNLV SLKTNSASKS APGCQEQTAN
NPTESDTLEF PNCPGSNHLP SSLSRSETKL QSNREISDIN QIHLARGELC DLQGRLQSVE
ESLHSNQEKI KVLLNVIQDL EKARALTEGR NFYRTGQDLN NCSTCQNTAC IIYSVEYDFR
QQEGRFHEVL QSLEEAEPVE EASPPPKSPA EPPAPEKQDL RRKTKKVKKK CFWWI
