ID   INY2B_MOUSE             Reviewed;         535 AA.
AC   Q6GQV1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=INSYN2B protein {ECO:0000305};
DE   AltName: Full=Inhibitory synaptic factor family member 2B {ECO:0000305};
GN   Name=Insyn2b; Synonyms=Fam196b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the INSYN2 family. {ECO:0000305}.
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DR   EMBL; BC072605; AAH72605.1; -; mRNA.
DR   CCDS; CCDS36127.1; -.
DR   RefSeq; NP_001020553.1; NM_001025382.2.
DR   RefSeq; XP_006514826.1; XM_006514763.3.
DR   AlphaFoldDB; Q6GQV1; -.
DR   STRING; 10090.ENSMUSP00000129183; -.
DR   iPTMnet; Q6GQV1; -.
DR   PhosphoSitePlus; Q6GQV1; -.
DR   PaxDb; Q6GQV1; -.
DR   PRIDE; Q6GQV1; -.
DR   ProteomicsDB; 271531; -.
DR   Antibodypedia; 64201; 10 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000093192; ENSMUSP00000090883; ENSMUSG00000069911.
DR   Ensembl; ENSMUST00000165963; ENSMUSP00000129183; ENSMUSG00000069911.
DR   GeneID; 574403; -.
DR   KEGG; mmu:574403; -.
DR   UCSC; uc011xsz.1; mouse.
DR   CTD; 100131897; -.
DR   MGI; MGI:3643491; Insyn2b.
DR   VEuPathDB; HostDB:ENSMUSG00000069911; -.
DR   eggNOG; ENOG502QT66; Eukaryota.
DR   GeneTree; ENSGT00530000063787; -.
DR   HOGENOM; CLU_543970_0_0_1; -.
DR   InParanoid; Q6GQV1; -.
DR   OMA; DIYHSPS; -.
DR   OrthoDB; 520296at2759; -.
DR   PhylomeDB; Q6GQV1; -.
DR   TreeFam; TF333465; -.
DR   BioGRID-ORCS; 574403; 2 hits in 70 CRISPR screens.
DR   PRO; PR:Q6GQV1; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q6GQV1; protein.
DR   Bgee; ENSMUSG00000069911; Expressed in subparaventricular zone and 103 other tissues.
DR   Genevisible; Q6GQV1; MM.
DR   InterPro; IPR029337; INSYN2.
DR   PANTHER; PTHR28682; PTHR28682; 1.
DR   Pfam; PF15265; FAM196; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..535
FT                   /note="INSYN2B protein"
FT                   /id="PRO_0000349184"
FT   REGION          23..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          411..448
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..293
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  59102 MW;  59B55C707396E516 CRC64;
     MAQQSMKVRP VLLKRSSLES VELVKQPHHR RSKSQQVRFK EDGNIKNPTG VTEVNTQTPE
     DPGVMGKAQA SRHHHPTTYS LSFPRSHKAG GFRSISIQTS PSLRKHFPVF KRKKLTTSKS
     LVEMPTASPS AIQVNGNLSE QDIVSSDLAF LRLAQHLEDG PRRLKIPHPF LPRMPKVQSN
     GPVSFCLESG TWMSSEKATA AIQVPDDICH SPTWEARESA LSPESSAEES NSIPALISMC
     PGDGQRVMTS ELERMPPCSN TNSSASNMPG TEKLTPELLL PKDNPDDKDL GLPSSQSKKM
     CVPSPPRTHS SPEPGSRSQP VHLGRSSDCP ASGDNHQDLE SLRSSSASKS VPVCWEHVTK
     LPSQSDTPEL QTGVGSEQLP ASIPRQENRA QSSREIGGSN HSHLAQGELC DLQGRLQSVE
     ESLHSNQEKI KVLLNVIQDL EKAHALTEGR NFYRTGQDLN NCSTCQNTAC IIYSVEYDFR
     QQEGRFHEVL QSLEEAEPTE EAPSPPKSPA EAPVPEKQDL RRKSKKVKKK CFWWI