IOD1_CHICK
ID IOD1_CHICK Reviewed; 245 AA.
AC O42411;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Type I iodothyronine deiodinase;
DE EC=1.21.99.4;
DE AltName: Full=5DI;
DE AltName: Full=DIOI;
DE AltName: Full=Type 1 DI;
DE AltName: Full=Type-I 5'-deiodinase;
DE Flags: Fragment;
GN Name=DIO1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=HYBRO; TISSUE=Liver;
RX PubMed=9389494; DOI=10.1210/endo.138.12.5599;
RA van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R.,
RA Leonard J.L., Visser T.J.;
RT "Expression of chicken hepatic type I and type III iodothyronine
RT deiodinases during embryonic development.";
RL Endocrinology 138:5144-5152(1997).
CC -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2
CC (3,3'-diiodothyronine). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC thyroxine; Xref=Rhea:RHEA:19745, ChEBI:CHEBI:13193,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:58448, ChEBI:CHEBI:533015; EC=1.21.99.4;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10107};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC {ECO:0000305}.
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DR EMBL; Y11110; CAA71996.1; -; mRNA.
DR PIR; JC5825; JC5825.
DR RefSeq; NP_001091083.1; NM_001097614.1.
DR STRING; 9031.ENSGALP00000017451; -.
DR PaxDb; O42411; -.
DR GeneID; 395940; -.
DR KEGG; gga:395940; -.
DR CTD; 1733; -.
DR VEuPathDB; HostDB:geneid_395940; -.
DR eggNOG; ENOG502QUGZ; Eukaryota.
DR InParanoid; O42411; -.
DR OrthoDB; 977776at2759; -.
DR PhylomeDB; O42411; -.
DR BRENDA; 1.21.99.4; 1306.
DR SABIO-RK; O42411; -.
DR PRO; PR:O42411; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004800; F:thyroxine 5'-deiodinase activity; IBA:GO_Central.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0042403; P:thyroid hormone metabolic process; IBA:GO_Central.
DR InterPro; IPR000643; Iodothyronine_deiodinase.
DR InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11781; PTHR11781; 1.
DR Pfam; PF00837; T4_deiodinase; 1.
DR PIRSF; PIRSF001330; IOD; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS01205; T4_DEIODINASE; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Oxidoreductase; Reference proteome;
KW Selenocysteine; Thyroid hormones biosynthesis; Transmembrane;
KW Transmembrane helix.
FT CHAIN <1..245
FT /note="Type I iodothyronine deiodinase"
FT /id="PRO_0000154315"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 123
FT NON_STD 123
FT /note="Selenocysteine"
FT NON_TER 1
SQ SEQUENCE 245 AA; 28386 MW; B5ED3C480884C3C1 CRC64;
LSIRVLLHKL LILLQVTLSV VVGKTMMILF PDTTKRYILK LGEKSRMNQN PKFSYENWGP
TFFSFQYLLF VLKVKWRRLE DEAHEGRPAP NTPVVALNGE MQHLFSFMRD NRPLILNFGS
CTUPSFMLKF DEFNKLVKDF SSIADFLIIY IEEAHAVDGW AFRNNVVIKN HRSLEDRKTA
AQFLQQKNPL CPVVLDTMEN LSSSKYAALP ERLYILQAGN VIYKGGVGPW NYHPQEIRAV
LEKLK
