IOD1_ORENI
ID IOD1_ORENI Reviewed; 248 AA.
AC O42449;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 29-SEP-2021, entry version 102.
DE RecName: Full=Type I iodothyronine deiodinase;
DE EC=1.21.99.4;
DE AltName: Full=5DI;
DE AltName: Full=DIOI;
DE AltName: Full=Type 1 DI;
DE AltName: Full=Type-I 5'-deiodinase;
GN Name=dio1;
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=9389495; DOI=10.1210/endo.138.12.5581;
RA Sanders J.P., van der Geyten S., Kaptein E., Darras V.M., Kuehn E.R.,
RA Leonard J.L., Visser T.J.;
RT "Characterization of a propylthiouracil-insensitive type I iodothyronine
RT deiodinase.";
RL Endocrinology 138:5153-5160(1997).
CC -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2
CC (3,3'-diiodothyronine).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC thyroxine; Xref=Rhea:RHEA:19745, ChEBI:CHEBI:13193,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:58448, ChEBI:CHEBI:533015; EC=1.21.99.4;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10107};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC {ECO:0000305}.
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DR EMBL; Y11109; CAA71995.1; -; mRNA.
DR RefSeq; NP_001266442.2; NM_001279513.2.
DR Ensembl; ENSONIT00000043403; ENSONIP00000047175; ENSONIG00000035478.
DR GeneID; 100534571; -.
DR KEGG; onl:100534571; -.
DR CTD; 1733; -.
DR GeneTree; ENSGT00940000154482; -.
DR InParanoid; O42449; -.
DR OrthoDB; 977776at2759; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004800; F:thyroxine 5'-deiodinase activity; IEA:UniProtKB-EC.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0061074; P:regulation of neural retina development; IEA:Ensembl.
DR InterPro; IPR000643; Iodothyronine_deiodinase.
DR InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR InterPro; IPR027252; Iodothyronine_deiodinase_I/III.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11781; PTHR11781; 1.
DR Pfam; PF00837; T4_deiodinase; 1.
DR PIRSF; PIRSF001330; IOD; 1.
DR PIRSF; PIRSF500144; IODI_III; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS01205; T4_DEIODINASE; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Oxidoreductase; Reference proteome;
KW Selenocysteine; Thyroid hormones biosynthesis; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..248
FT /note="Type I iodothyronine deiodinase"
FT /id="PRO_0000154316"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 126
FT NON_STD 126
FT /note="Selenocysteine"
SQ SEQUENCE 248 AA; 28210 MW; EB42DE7138551F87 CRC64;
MFLQKIVLYL STACMFCYML GKFLMLVILQ FFSPSLAKKF ILRMGEKITM TQNPRFNYED
WGLTFMSLAF IKTASSHMWL SLGEEAFVGG EAPDSPVVTM DREKTSISKY LKGNRPLVLS
FGSCTUPPFM YKLDEFKQLV KDFSDVADFL VIYIAEAHST DGWAFKNNYD INQHQSLEDR
LSAAQVLVQS EPLCPVVVDE MTDVTTIKYG ALPERLFILQ AGKVLYKGGK GPWGYNPAEV
RSFLEKIK
