IOD2_FUNHE
ID IOD2_FUNHE Reviewed; 266 AA.
AC P79747; Q8QFX5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 4.
DT 23-FEB-2022, entry version 102.
DE RecName: Full=Type II iodothyronine deiodinase;
DE EC=1.21.99.4;
DE AltName: Full=5DII;
DE AltName: Full=DIOII;
DE AltName: Full=Type 2 DI;
DE AltName: Full=Type-II 5'-deiodinase;
GN Name=dio2;
OS Fundulus heteroclitus (Killifish) (Mummichog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae; Fundulus.
OX NCBI_TaxID=8078;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=9002998; DOI=10.1210/endo.138.2.4904;
RA Valverde C., Croteau W., Lafleur G.J. Jr., Orozco A., St Germain D.L.;
RT "Cloning and expression of a 5'-iodothyronine deiodinase from the liver of
RT Fundulus heteroclitus.";
RL Endocrinology 138:642-648(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND SEQUENCE REVISION TO 109.
RX PubMed=12392690; DOI=10.1016/s0016-6480(02)00071-0;
RA Orozco A., Jeziorski M.C., Linser P.J., Greenberg R.M., Valverde-R C.;
RT "Cloning of the gene and complete cDNA encoding a type 2 deiodinase from
RT Fundulus heteroclitus.";
RL Gen. Comp. Endocrinol. 128:162-167(2002).
CC -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for
CC providing the brain with appropriate levels of T3 during the critical
CC period of development. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC thyroxine; Xref=Rhea:RHEA:19745, ChEBI:CHEBI:13193,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:58448, ChEBI:CHEBI:533015; EC=1.21.99.4;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10107};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC {ECO:0000305}.
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DR EMBL; U70869; AAB39651.2; -; mRNA.
DR EMBL; AY065833; AAC79662.2; -; mRNA.
DR EMBL; AY065834; AAL62449.1; -; Genomic_DNA.
DR RefSeq; NP_001296885.1; NM_001309956.1.
DR STRING; 8078.ENSFHEP00000014289; -.
DR GeneID; 105917782; -.
DR CTD; 1734; -.
DR OrthoDB; 977776at2759; -.
DR Proteomes; UP000265000; Whole Genome Shotgun Assembly.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004800; F:thyroxine 5'-deiodinase activity; ISS:UniProtKB.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0042403; P:thyroid hormone metabolic process; ISS:UniProtKB.
DR InterPro; IPR000643; Iodothyronine_deiodinase.
DR InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11781; PTHR11781; 1.
DR Pfam; PF00837; T4_deiodinase; 1.
DR PIRSF; PIRSF001330; IOD; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS01205; T4_DEIODINASE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Oxidoreductase; Selenocysteine; Thyroid hormones biosynthesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Type II iodothyronine deiodinase"
FT /id="PRO_0000154321"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 134
FT NON_STD 134
FT /note="Selenocysteine"
FT CONFLICT 109
FT /note="T -> A (in Ref. 1; AAB39651)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29678 MW; 99E44E44888B3A6F CRC64;
MGSASEDLLV TLQILPGFFS NCLFLALYDS VVLVKRVVAL LSRSRSAGCG EWRRMLTSEG
LRSIWNSFLL DAHKQVKLGC EAPNSKVVKV PDGPRWSSTV VPCGSRIQTG GECRLLDFES
SDRPLVVNFG SATUPPFISH LPAFRQLVED FSDVADFLLV YIDEAHPSDG WVAPQMGACS
FSFRKHQNLE ERIGAARKLI EHFSLPPQCQ LVADCMDNNA NVAYGVANER VCIVHQRKIA
YLGGKGPFFY SLKDVRQWLE LSYGRR