IOD3_CHICK
ID IOD3_CHICK Reviewed; 258 AA.
AC O42412;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Thyroxine 5-deiodinase;
DE EC=1.21.99.3;
DE AltName: Full=5DIII;
DE AltName: Full=DIOIII;
DE AltName: Full=Type 3 DI;
DE AltName: Full=Type III iodothyronine deiodinase;
DE Flags: Fragment;
GN Name=DIO3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=HYBRO; TISSUE=Liver;
RX PubMed=9389494; DOI=10.1210/endo.138.12.5599;
RA van der Geyten S., Sanders J.P., Kaptein E., Darras V.M., Kuehn E.R.,
RA Leonard J.L., Visser T.J.;
RT "Expression of chicken hepatic type I and type III iodothyronine
RT deiodinases during embryonic development.";
RL Endocrinology 138:5144-5152(1997).
CC -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3
CC (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine).
CC {ECO:0000250|UniProtKB:P49897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC thyroxine; Xref=Rhea:RHEA:18897, ChEBI:CHEBI:13193,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:57261, ChEBI:CHEBI:58448; EC=1.21.99.3;
CC Evidence={ECO:0000250|UniProtKB:P49897};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250};
CC Single-pass type II membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC {ECO:0000305}.
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DR EMBL; Y11273; CAA72136.1; -; mRNA.
DR RefSeq; NP_001116120.1; NM_001122648.2.
DR PaxDb; O42412; -.
DR GeneID; 395939; -.
DR KEGG; gga:395939; -.
DR CTD; 1735; -.
DR VEuPathDB; HostDB:geneid_395939; -.
DR InParanoid; O42412; -.
DR OrthoDB; 977776at2759; -.
DR PhylomeDB; O42412; -.
DR BRENDA; 1.21.99.3; 1306.
DR PRO; PR:O42412; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004800; F:thyroxine 5'-deiodinase activity; IBA:GO_Central.
DR GO; GO:0033798; F:thyroxine 5-deiodinase activity; IEA:UniProtKB-EC.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0042403; P:thyroid hormone metabolic process; IBA:GO_Central.
DR InterPro; IPR000643; Iodothyronine_deiodinase.
DR InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR InterPro; IPR027252; Iodothyronine_deiodinase_I/III.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11781; PTHR11781; 1.
DR Pfam; PF00837; T4_deiodinase; 1.
DR PIRSF; PIRSF001330; IOD; 1.
DR PIRSF; PIRSF500144; IODI_III; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS01205; T4_DEIODINASE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; Membrane; Oxidoreductase; Reference proteome;
KW Selenocysteine; Signal-anchor; Thyroid hormones biosynthesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..258
FT /note="Thyroxine 5-deiodinase"
FT /id="PRO_0000154326"
FT TRANSMEM <1..20
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 21..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ACT_SITE 122
FT NON_STD 122
FT /note="Selenocysteine"
FT NON_TER 1
SQ SEQUENCE 258 AA; 28876 MW; 029C543E492988C1 CRC64;
AACILLFPRF LLTAVMLWLL DFLCIRKKML TMPTAEEAAG AGEGPPPDDP PVCVSDSNRM
FTLESLKAVW HGQKLDFFKS AHVGSPAPNP EVIQLDGQKR LRILDFARGK RPLILNFGSC
TUPPFMARLR SFRRLAADFV DIADFLLVYI EEAHPSDGWV SSDAAYSIPK HQCLQDRLRA
AQLMREGAPD CPLAVDTMDN ASSAAYGAYF ERLYVIQEEK VMYQGGRGPE GYKISELRTW
LDQYKTRLQS PGAVVIQV
