IOD3_LITCT
ID IOD3_LITCT Reviewed; 269 AA.
AC P49898;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 29-SEP-2021, entry version 95.
DE RecName: Full=Thyroxine 5-deiodinase;
DE EC=1.21.99.3;
DE AltName: Full=5DIII;
DE AltName: Full=DIOIII;
DE AltName: Full=Type 3 DI;
DE AltName: Full=Type III iodothyronine deiodinase;
GN Name=dio3; Synonyms=itdi3, txdi3;
OS Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8400;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tail;
RX PubMed=7664662; DOI=10.1210/endo.136.10.7664662;
RA Becker K.B., Schneider M.J., Davey J.C., Galton V.A.;
RT "The type III 5-deiodinase in Rana catesbeiana tadpoles is encoded by a
RT thyroid hormone-responsive gene.";
RL Endocrinology 136:4424-4431(1995).
CC -!- FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-
CC tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3
CC (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). May play a
CC major role in regulating intracellular T3 levels in developing
CC tadpoles.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-
CC thyroxine; Xref=Rhea:RHEA:18897, ChEBI:CHEBI:13193,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16382, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:57261, ChEBI:CHEBI:58448; EC=1.21.99.3;
CC Evidence={ECO:0000250|UniProtKB:P49897};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250};
CC Single-pass type II membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the iodothyronine deiodinase family.
CC {ECO:0000305}.
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DR EMBL; L41731; AAA82941.2; -; mRNA.
DR PIR; I51163; I51163.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004800; F:thyroxine 5'-deiodinase activity; IEA:InterPro.
DR GO; GO:0033798; F:thyroxine 5-deiodinase activity; IEA:UniProtKB-EC.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR000643; Iodothyronine_deiodinase.
DR InterPro; IPR008261; Iodothyronine_deiodinase_AS.
DR InterPro; IPR027252; Iodothyronine_deiodinase_I/III.
DR PANTHER; PTHR11781; PTHR11781; 1.
DR Pfam; PF00837; T4_deiodinase; 1.
DR PIRSF; PIRSF001330; IOD; 1.
DR PIRSF; PIRSF500144; IODI_III; 1.
DR PROSITE; PS01205; T4_DEIODINASE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; Membrane; Oxidoreductase; Selenocysteine;
KW Signal-anchor; Thyroid hormones biosynthesis; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..269
FT /note="Thyroxine 5-deiodinase"
FT /id="PRO_0000154327"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT ACT_SITE 133
FT NON_STD 133
FT /note="Selenocysteine"
SQ SEQUENCE 269 AA; 30140 MW; 2F74465F46515FEB CRC64;
MLPAPHTCCR LLQQLLACCL LLPRFLLTVL LLWLLDFPCV RRRVIRGAKE EDPGAPERED
PPLCVSDTNR MCTLESLKAV WYGQKLDFFK SAHLGGGAPN TEVVTLEGQR LCRILDFSKG
HRPLVLNFGS CTUPPFMARL QAYQRLAAQR LDFADFLLVY IEEAHPCDGW LSTDAAYQIP
THQCLQDRLR AAQLMLQGAP GCRVVADTMT NASNAAYGAY FERLYVILDG KVVYQGGRGP
EGYKIGELRN WLDQYQTRAT GNGALVIQV
