IOJAP_BACSU
ID IOJAP_BACSU Reviewed; 118 AA.
AC P54457;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Ribosomal silencing factor RsfS {ECO:0000255|HAMAP-Rule:MF_01477};
GN Name=rsfS {ECO:0000255|HAMAP-Rule:MF_01477}; Synonyms=yqeL;
GN OrderedLocusNames=BSU25620;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Functions as a ribosomal silencing factor. Interacts with
CC ribosomal protein L14 (rplN), blocking formation of intersubunit bridge
CC B8. Prevents association of the 30S and 50S ribosomal subunits and the
CC formation of functional ribosomes, thus repressing translation.
CC {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SUBUNIT: Interacts with ribosomal protein L14 (rplN).
CC {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SIMILARITY: Belongs to the Iojap/RsfS family. {ECO:0000255|HAMAP-
CC Rule:MF_01477}.
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DR EMBL; D84432; BAA12449.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14504.1; -; Genomic_DNA.
DR PIR; H69951; H69951.
DR RefSeq; NP_390440.1; NC_000964.3.
DR RefSeq; WP_003229971.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54457; -.
DR SMR; P54457; -.
DR STRING; 224308.BSU25620; -.
DR PaxDb; P54457; -.
DR PRIDE; P54457; -.
DR EnsemblBacteria; CAB14504; CAB14504; BSU_25620.
DR GeneID; 937819; -.
DR KEGG; bsu:BSU25620; -.
DR PATRIC; fig|224308.179.peg.2785; -.
DR eggNOG; COG0799; Bacteria.
DR InParanoid; P54457; -.
DR OMA; VVHVFQK; -.
DR PhylomeDB; P54457; -.
DR BioCyc; BSUB:BSU25620-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0090071; P:negative regulation of ribosome biogenesis; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR Gene3D; 3.30.460.10; -; 1.
DR HAMAP; MF_01477; Iojap_RsfS; 1.
DR InterPro; IPR004394; Iojap/RsfS/C7orf30.
DR InterPro; IPR043519; NT_sf.
DR PANTHER; PTHR21043; PTHR21043; 1.
DR SUPFAM; SSF81301; SSF81301; 1.
DR TIGRFAMs; TIGR00090; rsfS_iojap_ybeB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repressor; Translation regulation.
FT CHAIN 1..118
FT /note="Ribosomal silencing factor RsfS"
FT /id="PRO_0000049787"
SQ SEQUENCE 118 AA; 13299 MW; BE9BBF9BDD8D53C4 CRC64;
MNQKSILKIA AAACDDKRAE DILALDMEGI SLVADYFLIC HGNSDKQVQA IAREIKDQAD
ENGIQVKKME GFDEARWVLV DLGDVVVHVF HKDERSYYNL EKLWGDAPLA DLDFGMNQ