IOJAP_HAEIN
ID IOJAP_HAEIN Reviewed; 102 AA.
AC P44471;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Ribosomal silencing factor RsfS {ECO:0000255|HAMAP-Rule:MF_01477};
GN Name=rsfS {ECO:0000255|HAMAP-Rule:MF_01477}; OrderedLocusNames=HI_0034;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Functions as a ribosomal silencing factor. Interacts with
CC ribosomal protein L14 (rplN), blocking formation of intersubunit bridge
CC B8. Prevents association of the 30S and 50S ribosomal subunits and the
CC formation of functional ribosomes, thus repressing translation.
CC {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SUBUNIT: Interacts with ribosomal protein L14 (rplN).
CC {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01477}.
CC -!- SIMILARITY: Belongs to the Iojap/RsfS family. {ECO:0000255|HAMAP-
CC Rule:MF_01477}.
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DR EMBL; L42023; AAC21712.1; -; Genomic_DNA.
DR PIR; H64140; H64140.
DR RefSeq; NP_438207.1; NC_000907.1.
DR RefSeq; WP_005635481.1; NC_000907.1.
DR AlphaFoldDB; P44471; -.
DR SMR; P44471; -.
DR STRING; 71421.HI_0034; -.
DR EnsemblBacteria; AAC21712; AAC21712; HI_0034.
DR KEGG; hin:HI_0034; -.
DR PATRIC; fig|71421.8.peg.34; -.
DR eggNOG; COG0799; Bacteria.
DR HOGENOM; CLU_092688_6_1_6; -.
DR OMA; VVHVFQK; -.
DR PhylomeDB; P44471; -.
DR BioCyc; HINF71421:G1GJ1-34-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0090071; P:negative regulation of ribosome biogenesis; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR Gene3D; 3.30.460.10; -; 1.
DR HAMAP; MF_01477; Iojap_RsfS; 1.
DR InterPro; IPR004394; Iojap/RsfS/C7orf30.
DR InterPro; IPR043519; NT_sf.
DR PANTHER; PTHR21043; PTHR21043; 1.
DR SUPFAM; SSF81301; SSF81301; 1.
DR TIGRFAMs; TIGR00090; rsfS_iojap_ybeB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repressor; Translation regulation.
FT CHAIN 1..102
FT /note="Ribosomal silencing factor RsfS"
FT /id="PRO_0000168677"
SQ SEQUENCE 102 AA; 11386 MW; BB84F9E4F385B5B7 CRC64;
MALVEFLMET LDGLKGTDIV HFDVRGKSSI TDNMIICTGT SSRQVSAMAD NLITECKKAG
FETFGEEGKN TADWIVVDLG QAIVHIMQRD AREMYQLEKL WA