ID   IOJAP_SYNY3             Reviewed;         154 AA.
AC   P73658;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Ribosomal silencing factor RsfS;
GN   Name=rsfS; OrderedLocusNames=slr1886;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [2]
RP   INTERACTION WITH RPLN.
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=22829778; DOI=10.1371/journal.pgen.1002815;
RA   Hauser R., Pech M., Kijek J., Yamamoto H., Titz B., Naeve F.,
RA   Tovchigrechko A., Yamamoto K., Szaflarski W., Takeuchi N., Stellberger T.,
RA   Diefenbacher M.E., Nierhaus K.H., Uetz P.;
RT   "RsfA (YbeB) proteins are conserved ribosomal silencing factors.";
RL   PLoS Genet. 8:E1002815-E1002815(2012).
CC   -!- FUNCTION: Functions as a ribosomal silencing factor. Interacts with
CC       ribosomal protein L14 (rplN), blocking formation of intersubunit bridge
CC       B8. Prevents association of the 30S and 50S ribosomal subunits and the
CC       formation of functional ribosomes, thus repressing translation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ribosomal protein L14 (rplN).
CC       {ECO:0000269|PubMed:22829778}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Iojap/RsfS family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA17703.1; -; Genomic_DNA.
DR   PIR; S77145; S77145.
DR   AlphaFoldDB; P73658; -.
DR   SMR; P73658; -.
DR   STRING; 1148.1652784; -.
DR   PaxDb; P73658; -.
DR   EnsemblBacteria; BAA17703; BAA17703; BAA17703.
DR   KEGG; syn:slr1886; -.
DR   eggNOG; COG0799; Bacteria.
DR   InParanoid; P73658; -.
DR   OMA; VVHVFQK; -.
DR   PhylomeDB; P73658; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0090071; P:negative regulation of ribosome biogenesis; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 3.30.460.10; -; 1.
DR   HAMAP; MF_01477; Iojap_RsfS; 1.
DR   InterPro; IPR004394; Iojap/RsfS/C7orf30.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR21043; PTHR21043; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
DR   TIGRFAMs; TIGR00090; rsfS_iojap_ybeB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Repressor; Translation regulation.
FT   CHAIN           1..154
FT                   /note="Ribosomal silencing factor RsfS"
FT                   /id="PRO_0000419626"
SQ   SEQUENCE   154 AA;  17090 MW;  C6890336B682341F CRC64;
     MTEISRFDAY PPTLTVNPIV PADAPATEHL VWTIAQAAEE RKAGDLVILK VTDVSYLADY
     FVICTGFSRT QVRAIADNIE KQVELVHGQL PTHTEGNSES IWVLQDFGDV LVHTFMPEER
     EFYKLEAFWG HAQEQTLADI ATAIGVAYNA PTSP