ID   IOJAP_TREPA             Reviewed;         111 AA.
AC   O83720;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Ribosomal silencing factor RsfS;
GN   Name=rsfS; OrderedLocusNames=TP_0738;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [2]
RP   INTERACTION WITH RPLN.
RC   STRAIN=Nichols;
RX   PubMed=22829778; DOI=10.1371/journal.pgen.1002815;
RA   Hauser R., Pech M., Kijek J., Yamamoto H., Titz B., Naeve F.,
RA   Tovchigrechko A., Yamamoto K., Szaflarski W., Takeuchi N., Stellberger T.,
RA   Diefenbacher M.E., Nierhaus K.H., Uetz P.;
RT   "RsfA (YbeB) proteins are conserved ribosomal silencing factors.";
RL   PLoS Genet. 8:E1002815-E1002815(2012).
CC   -!- FUNCTION: Functions as a ribosomal silencing factor. Interacts with
CC       ribosomal protein L14 (rplN), blocking formation of intersubunit bridge
CC       B8. Prevents association of the 30S and 50S ribosomal subunits and the
CC       formation of functional ribosomes, thus repressing translation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ribosomal protein L14 (rplN).
CC       {ECO:0000269|PubMed:22829778}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Iojap/RsfS family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65706.1; -; Genomic_DNA.
DR   PIR; G71288; G71288.
DR   RefSeq; WP_010882183.1; NC_021490.2.
DR   AlphaFoldDB; O83720; -.
DR   SMR; O83720; -.
DR   IntAct; O83720; 66.
DR   STRING; 243276.TPANIC_0738; -.
DR   EnsemblBacteria; AAC65706; AAC65706; TP_0738.
DR   KEGG; tpa:TP_0738; -.
DR   eggNOG; COG0799; Bacteria.
DR   HOGENOM; CLU_092688_5_0_12; -.
DR   OMA; HLMSEKS; -.
DR   OrthoDB; 1990650at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042256; P:mature ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0090071; P:negative regulation of ribosome biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.460.10; -; 1.
DR   HAMAP; MF_01477; Iojap_RsfS; 1.
DR   InterPro; IPR004394; Iojap/RsfS/C7orf30.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR21043; PTHR21043; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
DR   TIGRFAMs; TIGR00090; rsfS_iojap_ybeB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Repressor; Translation regulation.
FT   CHAIN           1..111
FT                   /note="Ribosomal silencing factor RsfS"
FT                   /id="PRO_0000419627"
SQ   SEQUENCE   111 AA;  12276 MW;  3BD58850899495C3 CRC64;
     MSANGAASAV AEALCDARAE DVCVFDVSAR CGWADFAVVA TVPGLLHGTH RLVCEQAARF
     GLREVHRKKR GLCEEQWRVL DFGSILVHLM SAQARAFYDL DRLWQDCLVA R