IOLB_ALKCK
ID IOLB_ALKCK Reviewed; 271 AA.
AC Q5WKZ0;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673}; OrderedLocusNames=ABC0423;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC {ECO:0000255|HAMAP-Rule:MF_01673}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
CC -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
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DR EMBL; AP006627; BAD62965.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5WKZ0; -.
DR SMR; Q5WKZ0; -.
DR STRING; 66692.ABC0423; -.
DR EnsemblBacteria; BAD62965; BAD62965; ABC0423.
DR KEGG; bcl:ABC0423; -.
DR eggNOG; COG3718; Bacteria.
DR HOGENOM; CLU_066438_1_0_9; -.
DR OMA; HGYDLYY; -.
DR UniPathway; UPA00076; UER00920.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; -; 2.
DR HAMAP; MF_01673; IolB; 1.
DR InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR InterPro; IPR023770; IolB_Bacilli.
DR InterPro; IPR021120; KduI/IolB_isomerase.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR39193; PTHR39193; 1.
DR Pfam; PF04962; KduI; 1.
DR PIRSF; PIRSF036628; IolB; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
DR TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome.
FT CHAIN 1..271
FT /note="5-deoxy-glucuronate isomerase"
FT /id="PRO_0000352383"
SQ SEQUENCE 271 AA; 30452 MW; 1492C688D632C19C CRC64;
MGQLLKKPKT KVLKQGVTLV HDTEAEKAPL KYVSFKLVDI QANAIYEETL GSYECCIVVV
RGTVTVTDGE HVFSNIGTRS SVFERKPTDS VYLSNGRSFT VTGTSEACIA LCYAPSNKQL
PTKLIKASDV GIENRGQLQN KRLVHNILPD SDKTANSLLV VEVFTESGNW SSYPPHKHDE
DNLPYESFLE ETYYHEIDPP QGFVFQRVYT ESRNIDETMA VENGDVVIVP AGYHPVGVPD
GYASYYLNVM AGPVRIWKFR NEKDHEWILS R