ID   IOLB_ALKHC              Reviewed;         270 AA.
AC   Q9KAG7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN   Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673}; OrderedLocusNames=BH2320;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC       5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC       {ECO:0000255|HAMAP-Rule:MF_01673}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC         Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC         EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
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DR   EMBL; BA000004; BAB06039.1; -; Genomic_DNA.
DR   PIR; H83939; H83939.
DR   RefSeq; WP_010898476.1; NC_002570.2.
DR   AlphaFoldDB; Q9KAG7; -.
DR   SMR; Q9KAG7; -.
DR   STRING; 272558.10174940; -.
DR   EnsemblBacteria; BAB06039; BAB06039; BAB06039.
DR   KEGG; bha:BH2320; -.
DR   eggNOG; COG3718; Bacteria.
DR   HOGENOM; CLU_066438_1_0_9; -.
DR   OMA; HGYDLYY; -.
DR   OrthoDB; 1047507at2; -.
DR   UniPathway; UPA00076; UER00920.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 2.
DR   HAMAP; MF_01673; IolB; 1.
DR   InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR   InterPro; IPR023770; IolB_Bacilli.
DR   InterPro; IPR021120; KduI/IolB_isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39193; PTHR39193; 1.
DR   Pfam; PF04962; KduI; 1.
DR   PIRSF; PIRSF036628; IolB; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..270
FT                   /note="5-deoxy-glucuronate isomerase"
FT                   /id="PRO_0000352384"
SQ   SEQUENCE   270 AA;  30481 MW;  773CB48FC265B6D0 CRC64;
     MSQLLRKPER AEISKGVTLV HDVTADNASL EYVSFKALDL SQGATYSETL ENKECCIVVV
     TGKVHVTDHE VTFENIGTRE SVFEKKPTDS VYVSNNQTFS IEAVTGARVA LCYAPSKNQL
     PTKLIKAEDN GVEHRGKGNN QRMVHNILPD SDPSANSLLV VEVFTESGNW SSYPPHKHDR
     DLLPEESLLE ETYYHEVNPK QGFVFQRVYT DDRSLDETMT VENENMVIVP KGYHPVGVPE
     GYASYYLNVM AGPKRIWKFF NDPAHEWIIE