IOLB_BACLD
ID IOLB_BACLD Reviewed; 271 AA.
AC Q65D01; Q62NH7;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673};
GN OrderedLocusNames=BLi04250, BL00245;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC {ECO:0000255|HAMAP-Rule:MF_01673}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
CC -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
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DR EMBL; CP000002; AAU25684.1; -; Genomic_DNA.
DR EMBL; AE017333; AAU43063.1; -; Genomic_DNA.
DR RefSeq; WP_003177822.1; NC_006322.1.
DR AlphaFoldDB; Q65D01; -.
DR SMR; Q65D01; -.
DR STRING; 279010.BL00245; -.
DR EnsemblBacteria; AAU25684; AAU25684; BL00245.
DR KEGG; bld:BLi04250; -.
DR KEGG; bli:BL00245; -.
DR PATRIC; fig|279010.13.peg.4334; -.
DR eggNOG; COG3718; Bacteria.
DR HOGENOM; CLU_066438_1_0_9; -.
DR OMA; HGYDLYY; -.
DR OrthoDB; 1047507at2; -.
DR BioCyc; BLIC279010:BLI_RS20900-MON; -.
DR UniPathway; UPA00076; UER00920.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; -; 2.
DR HAMAP; MF_01673; IolB; 1.
DR InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR InterPro; IPR023770; IolB_Bacilli.
DR InterPro; IPR021120; KduI/IolB_isomerase.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR39193; PTHR39193; 1.
DR Pfam; PF04962; KduI; 1.
DR PIRSF; PIRSF036628; IolB; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
DR TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome.
FT CHAIN 1..271
FT /note="5-deoxy-glucuronate isomerase"
FT /id="PRO_0000352385"
SQ SEQUENCE 271 AA; 30746 MW; 3F26518A09AF2E5A CRC64;
MSHLLRKPQA NELSQGVKLV HEVKKSNSDL SYVEFKVLDL APGSSYEESL SKQECCIVAL
TGKITATDHE QTFENIGTRE SVFERKPTDS VYVSNDRKFG ITAVTEARVA LCYSPSENQL
PTKLIKAEDN GIENRGKFSN KRTVHNILPD SDPSANSLLV VEVYTESGNW SSYPPHKHDQ
DNLPEESFLE ETYYHELDPQ QGFVFQRVYT DDRSIDETMT VENGNVVIVP AGYHPVGVPD
GYTSYYLNVM AGPTRKWKFH NDPDHEWILE R
