ID   IOLB_BACNA              Reviewed;         271 AA.
AC   A7BJC5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN   Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673};
OS   Bacillus subtilis subsp. natto.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=86029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Miyagino;
RX   PubMed=17928718; DOI=10.1271/bbb.70223;
RA   Kimura K., Itoh Y.;
RT   "Determination and characterization of IS4Bsu1-insertion loci and
RT   identification of a new insertion sequence element of the IS256 family in a
RT   natto starter.";
RL   Biosci. Biotechnol. Biochem. 71:2458-2464(2007).
CC   -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC       5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC       {ECO:0000255|HAMAP-Rule:MF_01673}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC         Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC         EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB304464; BAF74777.1; -; Genomic_DNA.
DR   RefSeq; WP_014481418.1; NZ_SJSU01000040.1.
DR   AlphaFoldDB; A7BJC5; -.
DR   SMR; A7BJC5; -.
DR   UniPathway; UPA00076; UER00920.
DR   GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 2.
DR   HAMAP; MF_01673; IolB; 1.
DR   InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR   InterPro; IPR023770; IolB_Bacilli.
DR   InterPro; IPR021120; KduI/IolB_isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39193; PTHR39193; 1.
DR   Pfam; PF04962; KduI; 1.
DR   PIRSF; PIRSF036628; IolB; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..271
FT                   /note="5-deoxy-glucuronate isomerase"
FT                   /id="PRO_0000352386"
SQ   SEQUENCE   271 AA;  30778 MW;  8CD7496AC9A9BEF5 CRC64;
     MSYLLRKPQS HEVSNGVKLV HEVTTSNSDL TYVEFKVLDL ASGSSYTEEL KKQEICIVAV
     TGKITVTDHE STFENIGTRE SVFERKPTDS VYISNDRAFE ITAVSDARVA LCYSPSEKQL
     PTKLIKAEDN GIEHRGQFSN KRTVHNILPD SDPSANSLLV VEVYTDSGNW SSYPPHKHDQ
     DNLPEESFLE ETYYHELDPG QGFVFQRVYT DDRSIDETMT VENENVVIVP AGYHPVGVPD
     GYTSYYLNVM AGPTRKWKFY NDPAHEWILE R