ID   IOLB_GEOTN              Reviewed;         274 AA.
AC   A4IPB4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN   Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673}; OrderedLocusNames=GTNG_1808;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC       5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC       {ECO:0000255|HAMAP-Rule:MF_01673}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC         Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC         EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
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DR   EMBL; CP000557; ABO67168.1; -; Genomic_DNA.
DR   RefSeq; WP_011887533.1; NC_009328.1.
DR   AlphaFoldDB; A4IPB4; -.
DR   SMR; A4IPB4; -.
DR   STRING; 420246.GTNG_1808; -.
DR   EnsemblBacteria; ABO67168; ABO67168; GTNG_1808.
DR   KEGG; gtn:GTNG_1808; -.
DR   eggNOG; COG3718; Bacteria.
DR   HOGENOM; CLU_066438_1_0_9; -.
DR   OMA; HGYDLYY; -.
DR   OrthoDB; 1047507at2; -.
DR   UniPathway; UPA00076; UER00920.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 2.
DR   HAMAP; MF_01673; IolB; 1.
DR   InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR   InterPro; IPR023770; IolB_Bacilli.
DR   InterPro; IPR021120; KduI/IolB_isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39193; PTHR39193; 1.
DR   Pfam; PF04962; KduI; 1.
DR   PIRSF; PIRSF036628; IolB; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..274
FT                   /note="5-deoxy-glucuronate isomerase"
FT                   /id="PRO_0000352388"
SQ   SEQUENCE   274 AA;  31184 MW;  3B73E28C860BA61E CRC64;
     MSRFIISSHS PNEEGNVVRV TPESAGWEYV GFEVYALTKG QTLRKETIDQ EACLVLLKGK
     ANIHTRHERW ENIGLRMDVF EKIPPYSVYV PSNDVYEVQA LTDLELAVCL APGKGTYPAR
     LIPPSEVGVE MRGAGNIERR IHNILPESKP ADSLLVVEVF TPEGNWSSYP PHKHDQHNLP
     HESYLEETYY HQINPDHGFM VQRVYTDDRS IDETMVVKNG DVVLVPKGYH PVSAPPGYEG
     YYLNVMAGPV RTWKFRNDPD HEWVMESKLA AKQK