ID   IOLB_LACCA              Reviewed;         271 AA.
AC   A5YBJ4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN   Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673};
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BL23;
RX   PubMed=17449687; DOI=10.1128/aem.00243-07;
RA   Yebra M.J., Zuniga M., Beaufils S., Perez-Martinez G., Deutscher J.,
RA   Monedero V.;
RT   "Identification of a gene cluster allowing Lactobacillus casei BL23 the
RT   utilization of myo-inositol.";
RL   Appl. Environ. Microbiol. 73:3850-3858(2007).
CC   -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC       5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC       {ECO:0000255|HAMAP-Rule:MF_01673}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC         Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC         EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
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DR   EMBL; EF382358; ABP57763.1; -; Genomic_DNA.
DR   RefSeq; WP_003573132.1; NZ_MODT01000071.1.
DR   AlphaFoldDB; A5YBJ4; -.
DR   SMR; A5YBJ4; -.
DR   STRING; 543734.LCABL_02180; -.
DR   PATRIC; fig|1582.47.peg.194; -.
DR   eggNOG; COG3718; Bacteria.
DR   OMA; HGYDLYY; -.
DR   UniPathway; UPA00076; UER00920.
DR   GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 2.
DR   HAMAP; MF_01673; IolB; 1.
DR   InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR   InterPro; IPR023770; IolB_Bacilli.
DR   InterPro; IPR021120; KduI/IolB_isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39193; PTHR39193; 1.
DR   Pfam; PF04962; KduI; 1.
DR   PIRSF; PIRSF036628; IolB; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..271
FT                   /note="5-deoxy-glucuronate isomerase"
FT                   /id="PRO_0000352389"
SQ   SEQUENCE   271 AA;  30814 MW;  BBEBD02E695B9C46 CRC64;
     MSLLYHKQNQ ELSSGVRLIQ DVNASNSPMK YTAVKVLEFS ADSSYEETLE AFEAGIVVLE
     GKVTITADDQ TFEDVGQRTS IFDKIPTDSV YVSTGLAFGI RAKQAAKILI AYAPTNQTFP
     VRLIRGNIHQ VEHRGKYNNK RLVQNILPDN LPFADKLLLV EVYTDSANWS SYPPHRHDHD
     DLPAESLLEE IYYHEMRPKQ GFVFQRVYTD DLSLDETMAV QNQDVVVVPK GYHPVGVPDG
     YDSYYLNVMA GPTRVWHFHN APEHAWIIDR Q