IOLB_LISIN
ID IOLB_LISIN Reviewed; 273 AA.
AC Q92EQ6;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673}; OrderedLocusNames=lin0402;
OS Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=272626;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-680 / CLIP 11262;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC {ECO:0000255|HAMAP-Rule:MF_01673}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
CC -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC Rule:MF_01673}.
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DR EMBL; AL596164; CAC95635.1; -; Genomic_DNA.
DR PIR; AC1483; AC1483.
DR RefSeq; WP_010990385.1; NC_003212.1.
DR AlphaFoldDB; Q92EQ6; -.
DR SMR; Q92EQ6; -.
DR STRING; 272626.lin0402; -.
DR EnsemblBacteria; CAC95635; CAC95635; CAC95635.
DR KEGG; lin:lin0402; -.
DR eggNOG; COG3718; Bacteria.
DR HOGENOM; CLU_066438_1_0_9; -.
DR OMA; HGYDLYY; -.
DR OrthoDB; 1047507at2; -.
DR UniPathway; UPA00076; UER00920.
DR Proteomes; UP000002513; Chromosome.
DR GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; -; 2.
DR HAMAP; MF_01673; IolB; 1.
DR InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR InterPro; IPR023770; IolB_Bacilli.
DR InterPro; IPR021120; KduI/IolB_isomerase.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR39193; PTHR39193; 1.
DR Pfam; PF04962; KduI; 1.
DR PIRSF; PIRSF036628; IolB; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
DR TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE 3: Inferred from homology;
KW Isomerase.
FT CHAIN 1..273
FT /note="5-deoxy-glucuronate isomerase"
FT /id="PRO_0000352390"
SQ SEQUENCE 273 AA; 30568 MW; 26B41A3654DE0D65 CRC64;
MGKLLRKPLN ERIAPGVTLV QDINQGNSPL SYVGFRLIEL EKGAVYQEAL TDLECCIVAL
TGKITVSEGD DIFAEIGTRA NVFEKIPTDS VFISGGRAFQ VKADTEKARV ALCYSPANRD
LPTTLIKASD NSIEQRGKYQ NKRLVHNILP DVSGVASSLL VVEVYTNGGN FSSYPPHKHD
RDNLPAESLL EESYYHEINP EQGFIFQRVY TDDRALDETM AVEHQNAVIV PEGYHPVGVP
DGYDSYYLNV MAGPKRVWKF HNDPDHEWIL ERD