ID   IOLB_LISMO              Reviewed;         273 AA.
AC   Q8Y9Y3;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=5-deoxy-glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            Short=5DG isomerase {ECO:0000255|HAMAP-Rule:MF_01673};
DE            EC=5.3.1.30 {ECO:0000255|HAMAP-Rule:MF_01673};
GN   Name=iolB {ECO:0000255|HAMAP-Rule:MF_01673}; OrderedLocusNames=lmo0384;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Involved in the isomerization of 5-deoxy-glucuronate (5DG) to
CC       5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).
CC       {ECO:0000255|HAMAP-Rule:MF_01673}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate;
CC         Xref=Rhea:RHEA:25840, ChEBI:CHEBI:16669, ChEBI:CHEBI:58852;
CC         EC=5.3.1.30; Evidence={ECO:0000255|HAMAP-Rule:MF_01673};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 4/7. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
CC   -!- SIMILARITY: Belongs to the isomerase IolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01673}.
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DR   EMBL; AL591975; CAC98463.1; -; Genomic_DNA.
DR   PIR; AI1122; AI1122.
DR   RefSeq; NP_463914.1; NC_003210.1.
DR   RefSeq; WP_010989445.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y9Y3; -.
DR   SMR; Q8Y9Y3; -.
DR   STRING; 169963.lmo0384; -.
DR   PaxDb; Q8Y9Y3; -.
DR   EnsemblBacteria; CAC98463; CAC98463; CAC98463.
DR   GeneID; 987640; -.
DR   KEGG; lmo:lmo0384; -.
DR   PATRIC; fig|169963.11.peg.397; -.
DR   eggNOG; COG3718; Bacteria.
DR   HOGENOM; CLU_066438_1_0_9; -.
DR   OMA; HGYDLYY; -.
DR   PhylomeDB; Q8Y9Y3; -.
DR   BioCyc; LMON169963:LMO0384-MON; -.
DR   UniPathway; UPA00076; UER00920.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0102482; F:5-deoxy-D-glucuronate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 2.
DR   HAMAP; MF_01673; IolB; 1.
DR   InterPro; IPR024203; Deoxy-glucuronate_isom_IolB.
DR   InterPro; IPR023770; IolB_Bacilli.
DR   InterPro; IPR021120; KduI/IolB_isomerase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39193; PTHR39193; 1.
DR   Pfam; PF04962; KduI; 1.
DR   PIRSF; PIRSF036628; IolB; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR04378; myo_inos_iolB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..273
FT                   /note="5-deoxy-glucuronate isomerase"
FT                   /id="PRO_0000352391"
SQ   SEQUENCE   273 AA;  30647 MW;  60E32E990CAB93E3 CRC64;
     MGKLLRKPLN ERIAPGVTLV QDINQGNSPL SYVGFRLIEL EEDAVYQETL DGLECCIVAL
     TGKISVSEGD HVFSEIGTRA NVFEKIPTDS VFISGGRAFQ VKADAEKARV ALCYSPADRN
     LPTTLIKASD NSIEQRGKYQ NKRLVHNILP DVSEVASSLL VVEVYTDGGN FSSYPPHKHD
     HDNLPAESLL EESYYHEINP KQGFIFQRVY TDDRALDETM AVEHQNAVIV PEGYHPVGVP
     DGYDSYYLNV MAGPKRVWEF HNDPDHEWIL ERD